{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:02:08Z","timestamp":1790892128493,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["AR21916B3C9E8EF7"],"award-info":[{"award-number":["AR21916B3C9E8EF7"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Microvascular complications' risk differs between people with latent autoimmune diabetes in adults (LADA) and people with type 2 diabetes. We aimed to investigate whether the prevalence of cardiac autonomic neuropathy, a life\u2010threatening complication of diabetes, also varies depending on diabetes type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, 43 adults with LADA, 80 with type 1 diabetes and 61 with type 2 diabetes were screened for cardiac autonomic neuropathy with recommended tests. Logistic regression models were used to test differences between diabetes types adjusting for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cardiac autonomic neuropathy was diagnosed in 17 (40%) participants with LADA, 21 (26%) participants with type 1 diabetes and 39 (64%) participants with type 2 diabetes (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The odds ratio (OR) for cardiac autonomic neuropathy in type 1 diabetes and in type 2 diabetes compared to LADA were 0.54 (95% CI: 0.25\u20131.20, <jats:italic>p<\/jats:italic>\u2010value: 0.13) and 2.71 (95% CI: 1.21\u20136.06, <jats:italic>p<\/jats:italic>\u2010value 0.015) respectively. Smoking (<jats:sub>adj<\/jats:sub>OR 3.09, 95% CI: 1.40\u20136.82, <jats:italic>p<\/jats:italic>\u2010value: 0.005), HDL cholesterol (<jats:sub>adj<\/jats:sub>OR 0.29, 95% CI: 0.09\u20130.93, <jats:italic>p<\/jats:italic>\u2010value: 0.037) and hypertension (<jats:sub>adj<\/jats:sub>OR 2.11, 95% CI: 1.05\u20134.24, <jats:italic>p<\/jats:italic>\u2010value: 0.037) were independent modifiable risk factors for cardiac autonomic neuropathy. Differences among diabetes types did not change after correction for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study offering a comparative evaluation of cardiac autonomic neuropathy among LADA, type 1 and type 2 diabetes, showing a lower risk of cardiac autonomic neuropathy in LADA compared to type 2 diabetes and similar compared to type 1 diabetes. This disparity was not due to differences in age, metabolic control or cardiovascular risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14455","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T22:50:35Z","timestamp":1605048635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Risk of cardiac autonomic neuropathy in latent autoimmune diabetes in adults is similar to type 1 diabetes and lower compared to type 2 diabetes: A cross\u2010sectional study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-9463","authenticated-orcid":false,"given":"Ernesto","family":"Maddaloni","sequence":"first","affiliation":[{"name":"Experimental Medicine Department Sapienza University of Rome Rome 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