{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:43:53Z","timestamp":1776084233687,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To summarize all relevant randomized controlled trials (RCTs) and provide precise effect estimates of glycaemic efficacy\/safety of faster\u2010acting insulin aspart administered by injection as compared to insulin aspart in people with diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed\/Cochrane Library were systematically searched till October 10, 2020, to identify RCTs with duration \u226516\u00a0weeks, evaluating efficacy\/safety of mealtime injections of faster aspart compared to insulin aspart in people with type 1 diabetes mellitus and type 2 diabetes mellitus. Studies using faster aspart as continuous subcutaneous insulin infusion were excluded. Continuous and dichotomous outcome variables (expressed as estimated treatment difference and rate ratio in RCTs, respectively) were pooled using generic inverse variance method with fixed\/random\u2010effects model. For each outcome variable, subgroup analysis between type 1 diabetes mellitus and type 2 diabetes mellitus was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included five RCTs; three of type 1 diabetes mellitus (n\u00a0=\u00a01963) and two of type 2 diabetes mellitus (n\u00a0=\u00a01780). All had low risk of bias. Faster aspart was associated with small but significant improvement in HbA<jats:sub>1c<\/jats:sub> than insulin aspart (MD: \u22120.06%, 95% CI: \u22120.10, \u22120.02, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a019%). HbA<jats:sub>1c<\/jats:sub> reduction was statistically significant only in type 1 diabetes mellitus on subgroup analysis (MD: \u22120.08%, 95% CI: \u22120.14, \u22120.02, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a047%). Besides, faster aspart was associated with reduced postprandial plasma glucose (PPG) increment at 1\u00a0h\/2\u00a0h after meal test and increased 1,5\u2010anhydroglucitol compared to insulin aspart. Early postprandial hypoglycaemic episodes were higher with faster aspart; however, overall and nocturnal hypoglycaemic episodes were not different from insulin aspart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Faster aspart is associated with reduced HbA<jats:sub>1c<\/jats:sub>, PPG increment and comparable overall hypoglycaemic episodes with regard to insulin aspart.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14515","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T04:07:56Z","timestamp":1610597276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Glycaemic efficacy and safety of mealtime faster\u2010acting insulin aspart administered by injection as compared to insulin aspart in people with diabetes mellitus: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-9393","authenticated-orcid":false,"given":"Rimesh","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Endocrinology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mainak","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Institute of Post Graduate Medical Education and Research Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay Kumar","family":"Bhadada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12501"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP171813.OR"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2019.01.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1771"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13205"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13545"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1770"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12955"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2232"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_10_13_1","unstructured":"Available from:https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42020211278."},{"key":"e_1_2_10_14_1","first-page":"29","article-title":"A revised tool for assessing risk of bias in randomized trials","volume":"10","author":"Higgins J","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_15_1","unstructured":"Meta\u2010analysis of counts and rates. 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