{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:37:36Z","timestamp":1791265056311,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1117061"],"award-info":[{"award-number":["1117061"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001792","name":"James Cook University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Topical oxygen therapy (TOT) has been suggested as a treatment for diabetes\u2010related foot ulcer (DFU) but no prior meta\u2010analyses of randomised clinical trials (RCT) have been reported. This systematic review and meta\u2010analysis examined the randomised evidence for the benefit of TOT in healing DFU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Publicly available databases were searched for RCTs investigating the effect of TOT on wound healing in participants with a DFU. The primary outcome was ulcer healing defined as full epithelialisation. Meta\u2010analyses were performed using random effect models and reported as risk ratios (RR) and 95% confidence intervals (CI). Study quality and publication bias were assessed using a modified version of the Cochrane Collaboration's tool and funnel plots, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six RCTs involving 530 participants with a DFU testing TOT were included. Meta\u2010analysis suggested that TOT significantly increased the likelihood of ulcer healing compared to controls (Risk ratio [RR] 1.94; 95% CI 1.19, 3.17; I<jats:sup>2<\/jats:sup>\u00a0=\u00a057%; NNT\u00a0=\u00a05.33) and findings were robust in sensitivity analyses. Risk of bias was high, moderate and low in two, one and three studies, respectively. Analysis of the three trials judged to be at low risk of bias suggested that TOT increased the likelihood of ulcer healing compared to controls (RR 2.37; 95% CI 1.52, 3.68; I<jats:sup>2<\/jats:sup>\u00a0=\u00a00%). Funnel plots suggested the possibility of publication bias. Data on amputation were too limited for meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis suggests that TOT improves the likelihood of DFU healing; however, its effect on amputation and cost\u2010effectiveness are unclear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14585","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T12:37:31Z","timestamp":1618835851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Topical oxygen therapy for diabetes\u2010related foot ulcers: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"38","author":[{"given":"Shivshankar","family":"Thanigaimani","sequence":"first","affiliation":[{"name":"The Queensland Research Centre for Peripheral Vascular Disease (QRC\u2010PVD) College of Medicine and Dentistry James Cook University Queensland Australia"},{"name":"The Australian Institute of Tropical Health and Medicine James Cook University Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejas","family":"Singh","sequence":"additional","affiliation":[{"name":"The Queensland Research Centre for Peripheral Vascular Disease (QRC\u2010PVD) College of Medicine and Dentistry James Cook University Queensland Australia"},{"name":"The Department of Vascular and Endovascular Surgery The Townsville University Hospital Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-8848","authenticated-orcid":false,"given":"Jonathan","family":"Golledge","sequence":"additional","affiliation":[{"name":"The Queensland Research Centre for Peripheral Vascular Disease (QRC\u2010PVD) College of Medicine and Dentistry James Cook University Queensland Australia"},{"name":"The Australian Institute of Tropical Health and Medicine James Cook University Townsville Queensland Australia"},{"name":"The Department of Vascular and Endovascular Surgery The Townsville University Hospital Townsville Queensland 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