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We assessed whether there was also evidence of temporal variation in maternal treatment requirements and early neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of women diagnosed with GDM (75\u00a0g oral glucose tolerance test, 0\u00a0h\u00a0\u2265\u00a05.1; 1\u00a0h\u00a0\u2265\u00a010.0; 2\u00a0h\u00a0\u2265\u00a08.5\u00a0mmol\/L) in a UK tertiary obstetric centre (2015\u20132019) with a singleton infant. Data regarding demographic characteristics, total insulin requirements and neonatal outcomes were extracted from contemporaneous electronic medical records. Linear\/logistic regression models using month of the year as a predictor of outcomes were used to assess annual variation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 791 women (50.6% receiving pharmacological treatment) and 790 neonates were included. The likelihood of requiring insulin treatment was highest in November (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The average total daily insulin dose was higher at peak (January) compared to average by 19\u00a0units\/day (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). There was no temporal variation in neonatal intensive care admission, or neonatal capillary blood glucose. However, rates of neonatal hypoglycaemia (defined as &lt;2.6\u00a0mmol\/L) were highest in December (40% above average; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with GDM diagnosed in winter are more likely to require insulin treatment and to require higher insulin doses. Neonates born to winter\u2010diagnosed mothers had a corresponding increased risk of neonatal hypoglycaemia. Maternal treatment requirements and neonatal outcomes of GDM vary significantly throughout the year, even in a relatively temperate climate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14596","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T06:23:24Z","timestamp":1620541404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Temporal variations in maternal treatment requirements and early neonatal outcomes in patients with gestational diabetes"],"prefix":"10.1111","volume":"38","author":[{"given":"Rachel A.","family":"Fox","sequence":"first","affiliation":[{"name":"School of Clinical Medicine Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte J.","family":"Patient","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Addenbrooke's Hospital Cambridge UK"},{"name":"Department of Obstetrics and Gynaecology Rosie Hospital Cambridge University Hospitals Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail R.","family":"Aiken","sequence":"additional","affiliation":[{"name":"LBJ School of Public Affairs University of Texas at Austin Austin TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-8329","authenticated-orcid":false,"given":"Claire L.","family":"Meek","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Science Addenbrooke's Hospital Cambridge UK"},{"name":"Department of Clinical Biochemistry Cambridge University Hospitals Addenbrooke's Hospital Cambridge UK"},{"name":"Wolfson Diabetes and Endocrinology Clinic Cambridge University Hospitals Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-5626","authenticated-orcid":false,"given":"Catherine 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