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Some summary messages emerge: The history of clinical diabetes research has shown how, perhaps through skilful leadership, combining very different personalities, skills and motivation can solve great challenges: Type 2 diabetes is a primary nutritional disease, secondary to the disease\u2010process of obesity, not a primary endocrine disease. Type 2 diabetes is a manifestation of <jats:italic>the disease<\/jats:italic>\u2010<jats:italic>process of obesity<\/jats:italic>, revealed by weight gain in people with underlying metabolic syndrome genetics\/diathesis, mediated in large part at least by reversible ectopic fat accumulation impairing function of organs (liver, pancreas, brown adipose tissue). Treat overweight\/obesity more seriously (defined as a <jats:italic>disease<\/jats:italic>\u2010<jats:italic>process with multiple organ<\/jats:italic>\u2010<jats:italic>specific complications<\/jats:italic>\u2014not as a disease\u2010state or BMI cut\u2010off). Discuss the complications and risks of T2D openly: remission is as important as for cancers. Offer and support an optimal dietary weight management program as soon as possible from diagnosis, specifically aiming for remission: (a) Warn against non\u2010evidence\u2010based programs that look similar or claim to have similar potential: we have fully evidence\u2010based programs; (b) Target sustained loss of &gt;15\u00a0kg for Europeans (possibly less, e.g. &gt;10\u00a0kg for Asians?). Increase future research support to enhance long\u2010term weight loss maintenance. Several approaches need consideration: (a) Personalise diet compositions (recognising there is no intrinsic advantage from different carbohydrate\/fat content). (b) Novel diet strategies (e.g. 5:2, time\u2010restricted, flexible diet compositions). (c) New pharmaceutical agents as adjuncts to diet if necessary. (d) Novel food supplements to increase endogenous GLP\u20101\u00a0secretion.<\/jats:p>","DOI":"10.1111\/dme.14643","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T19:43:21Z","timestamp":1626810201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Banting Memorial Lecture 2021\u2014Banting, banting, banter and bravado: Convictions meet evidence in the scientific process"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-0083","authenticated-orcid":false,"given":"Michael E. 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