{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:55:06Z","timestamp":1785041706254,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetic foot ulceration (DFU) is a challenging clinical problem that affects up to a quarter of patients with diabetes in their lifetime. An agreed set of outcomes for assessing treatments or interventions for DFU has not previously been considered. The aim of this study was to identify outcomes that are reported in clinical studies assessing a treatment or intervention for DFU, to inform the development of a core outcome set (COS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic literature searches were performed between January 2016 and March 2019. The search strategy was pre\u2010registered with PROSPERO (CRD42019128250). Two authors independently screened abstracts for full text review. Outcomes were extracted from selected papers verbatim and categorized into domains according to established taxonomy. Consistency of outcome reporting was assessed. Overlapping outcomes were merged independently to condense the extracted list of outcomes for use in forthcoming consensus processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4645 abstracts identified, 114 studies met the inclusion criteria. There were 69 randomized studies, 40 prospective studies and 5 protocols. Some 948 outcomes were extracted verbatim. Outcome reporting was consistent for 474 (53%) outcomes. De\u2010duplication left 714 unique verbatim outcomes across 33 domains. Merging of overlapping unique verbatim outcomes established 95 merged outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study describes contemporary outcomes reported in studies assessing interventions for DFU. Outcome reporting is considered to be poor as it was consistent in just over half of outcomes extracted. Merging of outcomes has identified 95 outcomes that can be taken forward in the development of a COS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14664","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T16:10:51Z","timestamp":1627575051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A systematic review of outcome reporting for interventions to treat people with diabetic foot ulceration"],"prefix":"10.1111","volume":"38","author":[{"given":"George","family":"Dovell","sequence":"first","affiliation":[{"name":"Centre for Surgical Research University of Bristol Bristol UK"},{"name":"Department of Vascular Surgery North Bristol NHS Trust Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Staniszewska","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery North Bristol NHS Trust Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozel","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Centre for Surgical Research University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery North Bristol NHS Trust Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme K.","family":"Ambler","sequence":"additional","affiliation":[{"name":"Centre for Surgical Research University of Bristol Bristol UK"},{"name":"Department of Vascular Surgery North Bristol NHS Trust Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Twine","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery North Bristol NHS Trust Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Hinchliffe","sequence":"additional","affiliation":[{"name":"Centre for Surgical Research University of Bristol Bristol UK"},{"name":"Department of Vascular Surgery North Bristol NHS Trust Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2740"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2699"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2018.0855"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6925357"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1978-4"},{"issue":"6","key":"e_1_2_8_8_1","first-page":"CD011038","article-title":"Topical antimicrobial agents for treating foot ulcers in people with diabetes","volume":"6","author":"Dumville JC","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"CD003556","article-title":"Debridement of diabetic foot ulcers","volume":"2010","author":"Edwards J","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"e_1_2_8_10_1","first-page":"CD008548","article-title":"Growth factors for treating diabetic foot ulcers","author":"Mart\u00ed\u2010Carvajal AJ","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"e_1_2_8_11_1","first-page":"CD009110","article-title":"Alginate dressings for healing diabetic foot ulcers","volume":"2013","author":"Dumville JC","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"e3266","DOI":"10.1002\/dmrr.3266","article-title":"Practical Guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update)","volume":"36","author":"Schaper NC","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002447"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_8_15_1","unstructured":"Core outcome measures in effectiveness trials. 2021. 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