{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:35:44Z","timestamp":1776278144048,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T00:00:00Z","timestamp":1628899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008303","name":"Department for Employment and Learning, Northern Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008303","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Given that diabetes is associated with cognitive impairment and dementia in later life, we aimed to investigate the relationship between glycated haemoglobin (HbA<jats:sub>1c<\/jats:sub>), diabetes and domain\u2010specific neuropsychological performance in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional cohort study using data from the Trinity\u2010Ulster\u2010Department of Agriculture (TUDA) study. Participants underwent detailed cognitive and neuropsychological assessment using the Mini\u2010Mental State Examination (MMSE), Frontal Assessment Battery (FAB) and Repeatable Assessment for Neuropsychological Status (RBANS). Linear regression was used to assess associations between HbA<jats:sub>1c<\/jats:sub>, diabetes status and neuropsychological performance, with adjustment for important clinical covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4938 older adults (74.1\u00a0\u00b1\u00a08.3\u00a0years; 66.9% female), 16.3% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0803) had diabetes (HbA<jats:sub>1c<\/jats:sub>\u00a0\u2265\u00a06.5%; 48\u00a0mmol\/mol), with prediabetes (HbA<jats:sub>1c<\/jats:sub>\u00a0\u2265\u00a05.7%\u20136.4%; 39\u201347\u00a0mmol\/mol) present in 28.3% (<jats:italic>n<\/jats:italic>\u00a0=\u00a01395). Increasing HbA<jats:sub>1c<\/jats:sub> concentration was associated with poorer overall performance on the FAB [\u03b2: \u22120.01 (\u22120.02, \u22120.00); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04 per % increase] and RBANS [\u03b2\u00a0=\u00a0\u22120.66 (\u22121.19, \u22120.13); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02 per % increase]. Increasing HbA<jats:sub>1c<\/jats:sub> was also associated with poorer performance on immediate memory, visuo\u2010spatial, language and attention RBANS domains. Diabetes was associated poorer performance on neuropsychological tests of immediate memory, language, visual\u2010spatial and attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both increasing HbA<jats:sub>1c<\/jats:sub> and the presence of diabetes were associated with poorer cognitive and domain\u2010specific performance in older adults. HbA<jats:sub>1c<\/jats:sub>, and not just diabetes status per se, may represent an important target in the promotion of optimal brain health in older adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14668","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T17:49:09Z","timestamp":1628012949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Glycated haemoglobin (HbA<sub>1c<\/sub>), diabetes and neuropsychological performance in community\u2010dwelling older adults"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1356-510X","authenticated-orcid":false,"given":"Adam H.","family":"Dyer","sequence":"first","affiliation":[{"name":"Mercer\u2019s Institute for Successful Ageing St James\u2019s Hospital Dublin Ireland"},{"name":"Department of Medical Gerontology School of Medicine Trinity College Dublin Ireland"},{"name":"Wellcome\u2010HRB Clinical Research Facility St James\u2019s Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-2692","authenticated-orcid":false,"given":"Robert","family":"Briggs","sequence":"additional","affiliation":[{"name":"Mercer\u2019s Institute for Successful Ageing St James\u2019s Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eamon","family":"Laird","sequence":"additional","affiliation":[{"name":"Department of Medical Gerontology School of Medicine Trinity College Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leane","family":"Hoey","sequence":"additional","affiliation":[{"name":"The Nutrition Innovation Centre for Food and Health (NICHE) School of Biomedical Sciences Ulster University Coleraine Northern Ireland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine F.","family":"Hughes","sequence":"additional","affiliation":[{"name":"The Nutrition Innovation Centre for Food and Health (NICHE) School of Biomedical Sciences Ulster University Coleraine Northern Ireland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"McNulty","sequence":"additional","affiliation":[{"name":"The Nutrition Innovation Centre for Food and Health (NICHE) School of Biomedical Sciences Ulster University Coleraine Northern Ireland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Ward","sequence":"additional","affiliation":[{"name":"The Nutrition Innovation Centre for Food and Health (NICHE) School of Biomedical Sciences Ulster University Coleraine Northern Ireland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JJ","family":"Strain","sequence":"additional","affiliation":[{"name":"The Nutrition Innovation Centre for Food and Health (NICHE) School of Biomedical Sciences Ulster University Coleraine Northern Ireland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M","family":"Molloy","sequence":"additional","affiliation":[{"name":"School of Medicine Trinity College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conal","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Mercer\u2019s Institute for Successful Ageing St James\u2019s Hospital Dublin Ireland"},{"name":"Department of Medical Gerontology School of Medicine Trinity College Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"McCarroll","sequence":"additional","affiliation":[{"name":"Mercer\u2019s Institute for Successful Ageing St James\u2019s Hospital Dublin Ireland"},{"name":"Department of Medical Gerontology School of Medicine Trinity College Dublin 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