{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:53:46Z","timestamp":1792518826091,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to evaluate the ability of HbA<jats:sub>1c<\/jats:sub> combined with glycated albumin (GA) or 1,5\u2010anhydroglucitol (1,5\u2010AG) to detect diabetes in residents of Jiangsu, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The oral glucose tolerance test (OGTT) was performed on 2184 people in Jiangsu. HbA<jats:sub>1c<\/jats:sub>, GA, 1,5\u2010AG and other serum biochemical parameters were measured. Receiver operating characteristic curves were plotted to determine the optimal thresholds of HbA<jats:sub>1c<\/jats:sub>, GA and 1,5\u2010AG according to the Youden index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(1) The optimal thresholds of HbA<jats:sub>1c<\/jats:sub>, GA and 1,5\u2010AG for the screening of diabetes were \u226545\u00a0mmol\/mol (6.3%), \u226513.0% and \u226423.0\u00a0\u03bcg\/ml, respectively. (2) The sensitivities of HbA<jats:sub>1c<\/jats:sub> combined with GA and 1,5\u2010AG were both 85%, higher than that of HbA<jats:sub>1c<\/jats:sub> (70%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is suitable for cases where plasma glucose is unavailable. Among the residents of Jiangsu, HbA<jats:sub>1c<\/jats:sub> combined with GA or 1,5\u2010AG can improve the sensitivity of diabetes screening, reduce the miss rate and save the use of OGTT. GA and 1,5\u2010AG are superior in individuals with mild glucose metabolism disorder. GA enhances the detection of diabetes in the nonobese, and 1,5\u2010AG enhances the detection in those with hyperuricaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14685","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T17:19:54Z","timestamp":1630603194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["HbA<sub>1c<\/sub> combined with glycated albumin or 1,5\u2010anhydroglucitol improves the efficiency of diabetes screening in a Chinese population"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-2753","authenticated-orcid":false,"given":"Junyi","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Endocrinology School of Medicine Zhongda Hospital Institute of Diabetes Southeast University  Nanjing 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