{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:28:08Z","timestamp":1760909288453,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Studies suggest that type 1 diabetes (T1D) contributes to impaired insulin sensitivity (IS). Most children with T1D experience partial remission but the knowledge regarding the magnitude and implications of impaired IS in this phase is limited. Therefore, we investigate the impact of IS on the partial remission phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a longitudinal study of children and adolescents, participants were seen at three clinical visits during the first 14.5\u00a0months after diagnosis of T1D. Partial remission was defined as IDAA<jats:sub>1c<\/jats:sub> (HbA<jats:sub>1c<\/jats:sub> (%)\u00a0+\u00a04*daily insulin dose)\u00a0\u2264\u00a09. Beta\u2010cell function was considered significant by a stimulated c\u2010peptide\u00a0&gt;\u00a0300\u00a0pmol\/L. Participants were characterized by (i) remission or non\u2010remission and (ii) stimulated c\u2010peptide levels above or below 300\u00a0pmol\/L. IS, body mass index (BMI), total body fat, sex, age, pubertal status and ketoacidosis at onset were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010eight children and adolescents aged 3.3\u201317.7\u00a0years were included. At 14.5\u00a0months post\u2010diagnosis, 54.5% of the participants with stimulated c\u2010peptide\u00a0&gt;\u00a0300\u00a0pmol\/L were not in partial remission. Participants not in remission had significant lower IS 2.5 (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.032), and 14.5 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.022) months after diagnosis compared to participants in partial remission with similar c\u2010peptide levels. IS did not fluctuate during the remission phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A number of children and adolescents have impaired IS in the remission phase of paediatric T1D and are not in remission 14.5\u00a0months after diagnosis despite stimulated c\u2010peptide\u00a0&gt;\u00a0300\u00a0pmol\/L.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14702","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T12:59:13Z","timestamp":1632661153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Differences in insulin sensitivity in the partial remission phase of childhood type 1 diabetes; a longitudinal cohort study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-2049","authenticated-orcid":false,"given":"Freja C. B.","family":"M\u00f8rk","sequence":"first","affiliation":[{"name":"Department of Clinical Research Steno Diabetes Center Copenhagen  Gentofte Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital, Herlev and Gentofte Hospital  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1186-4683","authenticated-orcid":false,"given":"Jens Otto B.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital, Herlev and Gentofte Hospital  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas K.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Copenhagen Biostatistics  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-8127","authenticated-orcid":false,"given":"Gerrit V.","family":"Hall","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Clinical Metabolomics Core Facility Department of Clinical Biochemistry Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-5229","authenticated-orcid":false,"given":"Kasper A.","family":"Pilgaard","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital, Herlev and Gentofte Hospital  Herlev Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine Nordsj\u00e6llands Hospital  Hiller\u00f8d Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3274-5448","authenticated-orcid":false,"given":"Flemming","family":"Pociot","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Steno Diabetes Center Copenhagen  Gentofte Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2772-2567","authenticated-orcid":false,"given":"Jesper","family":"Johannesen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital, Herlev and Gentofte Hospital  Herlev Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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