{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:21:15Z","timestamp":1753878075121,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14OC0009275"],"award-info":[{"award-number":["NNF14OC0009275"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the impact of anti\u2010hypertensive treatment of pregnancy\u2010induced hypertension on foetal growth and hemodynamics in women with pre\u2010existing diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study of 247 consecutive pregnant women with pre\u2010existing diabetes (152 type 1 diabetes; 95 type 2 diabetes), where tight anti\u2010hypertensive treatment was initiated and intensified (mainly with methyldopa) when office blood pressure (BP) \u2265135\/85\u00a0mmHg and home BP \u2265130\/80\u00a0mmHg. Foetal growth was assessed by ultrasound at 27, 33 and 36\u00a0weeks and foetal hemodynamics were assessed by ultrasound Doppler before and 1\u20132\u00a0weeks after initiation of anti\u2010hypertensive treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 215 initially normotensive women, anti\u2010hypertensive treatment for pregnancy\u2010induced hypertensive disorders was initiated in 42 (20%), whilst 173 were left untreated. Chronic hypertension was present in 32 (13%). Anti\u2010hypertensive treatment for pregnancy\u2010induced hypertensive disorders was not associated with foetal growth deviation (linear mixed model, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.681). At 27\u00a0weeks, mainly before initiation of anti\u2010hypertensive treatment, the prevalence of small foetuses with an estimated foetal weight &lt;10th percentile was 12% in women initiating anti\u2010hypertensive treatment compared with 4% in untreated women (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.054). These numbers were close to the prevalence of birth weight \u226410th percentile (small for gestational age (SGA)) (17% vs. 4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). Pulsatility index in the umbilical and middle cerebral artery remained stable after the onset of anti\u2010hypertensive treatment in a representative subgroup (<jats:italic>n<\/jats:italic>\u00a0=\u00a012, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.941 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.799, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is no clear indication that antihypertensive treatment causes harm in this particular at\u2010high\u2010risk group of pregnant women with diabetes, such that a larger well\u2010designed study to determine the value of tight antihypertensive control would be worthwhile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14722","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T18:57:42Z","timestamp":1634497062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of anti\u2010hypertensive treatment on foetal growth and haemodynamics in pregnant women with pre\u2010existing diabetes \u2013 An explorative study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-8253","authenticated-orcid":false,"given":"Marianne","family":"Vestgaard","sequence":"first","affiliation":[{"name":"Center for Pregnant Women with Diabetes Departments of Endocrinology and Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaf","family":"Al\u2010Saudi","sequence":"additional","affiliation":[{"name":"Center for Pregnant Women with Diabetes Departments of Endocrinology and Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rg","family":"\u00c1sbj\u00f6rnsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Center for Pregnant Women with Diabetes Departments of Endocrinology and Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone N.","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berit Woetman","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte Kvist","family":"Ekelund","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene","family":"Ringholm","sequence":"additional","affiliation":[{"name":"Center for Pregnant Women with Diabetes Departments of Endocrinology and Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise Lotte T.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte M.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Odense University Hospital  Odense Denmark"},{"name":"Steno Diabetes Center Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Tabor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Damm","sequence":"additional","affiliation":[{"name":"Center for Pregnant Women with Diabetes Departments of Endocrinology and Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth R.","family":"Mathiesen","sequence":"additional","affiliation":[{"name":"Center for Pregnant Women with Diabetes Departments of Endocrinology and Obstetrics Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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