{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:46:24Z","timestamp":1770702384354,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015223","name":"Danish Diabetes Academy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015223","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Adolescent offspring exposed to maternal diabetes during intrauterine life show a less favourable metabolic profile than the background population. Here, we hypothesize that offspring of women with type 1 diabetes (T1D), possess sex\u2010specific alterations in the serum profile of proteins involved in lipid, metabolic and transport processes and that these alterations are associated with lipid profile and indices of insulin sensitivity and secretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective nationwide follow\u2010up study (EPICOM) in a Danish population. Blood samples were assessed from offspring of women with T1D (index offspring, <jats:italic>n<\/jats:italic>\u00a0=\u00a0267, 13\u201320\u00a0years), and matched control offspring (<jats:italic>n<\/jats:italic>\u00a0=\u00a0290). Serum proteins were analysed using a 25\u2010plex cardio\u2010metabolic targeted proteomics assay, which includes 12 apolipoproteins and 13 transport and inflammatory proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Apolipoprotein D (ApoD) and transthyretin (TTR) were reduced in index females as compared to female controls (\u22128.1%, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001 and \u22126.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.006 respectively), but not in index males (2.2%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.476 and \u22122.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.731 respectively). Sex\u2010dependent inverse associations between exposure to maternal T1D in utero and ApoD and TTR were significant after adjusting for age, BMI\u2010SDS and Tanner stage (OR\u00a0=\u00a00.252 [95% CI 0.085, 0.745], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.013 and OR\u00a0=\u00a00.149 [95% CI 0.040, 0.553], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). ApoD correlated to indices of insulin sensitivity and secretion in a similar sex\u2010specific pattern in crude and adjusted analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low ApoD may be regarded as an early risk marker of metabolic syndrome. A possible link between ApoD and cardiovascular disease needs further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14776","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T15:36:04Z","timestamp":1640273764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Apolipoprotein D and transthyretin are reduced in female adolescent offspring of women with type 1 diabetes: The EPICOM study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-590X","authenticated-orcid":false,"given":"Martin","family":"Overgaard","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry and Pharmacology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Ravnsborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Pharmacology Odense University Hospital  Odense Denmark"},{"name":"The Danish Diabetes Academy Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Lohse","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Odense Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Bytoft","sequence":"additional","affiliation":[{"name":"Center for Pregnant Women with Diabetes Department of Obstetrics Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine\u00a0D.","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Nordsjaellands Hospital  Hilleroed Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke B.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-5246","authenticated-orcid":false,"given":"Peter","family":"Damm","sequence":"additional","affiliation":[{"name":"Center for Pregnant Women with Diabetes Department of Obstetrics Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"H\u00f8jlund","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Steno Diabetes Center Odense Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-1720","authenticated-orcid":false,"given":"Claus\u00a0H.","family":"Gravholt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sine","family":"Knorr","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-9824","authenticated-orcid":false,"given":"Dorte M.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Steno Diabetes Center Odense Odense University Hospital  Odense Denmark"},{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"B142","article-title":"Long\u2010term effects of the intrauterine environment. 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