{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T17:05:38Z","timestamp":1788109538384,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We investigated the current extent of undiagnosed diabetes and prediabetes and their associated cardiovascular risk profile in a population\u2010based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All residents aged \u226520 years in the Nord\u2010Tr\u00f8ndelag region, Norway, were invited to the HUNT4 Survey in 2017\u20132019, and 54% attended. Diagnosed diabetes was self\u2010reported, and in those reporting no diabetes HbA1c was used to classify undiagnosed diabetes (\u226548\u00a0mmol\/mol [6.5%]) and prediabetes (39\u201347\u00a0mmol\/mol [5.7%\u20136.4%]). We estimated the age\u2010 and sex\u2010standardized prevalence of these conditions and their age\u2010 and sex\u2010adjusted associations with other cardiovascular risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 52,856 participants, the prevalence of diabetes was 6.0% (95% CI 5.8, 6.2), of which 11.1% were previously undiagnosed (95% CI 10.1, 12.2). The prevalence of prediabetes was 6.4% (95% CI 6.2, 6.6). Among participants with undiagnosed diabetes, 58% had HbA1c of 48\u201353\u00a0mmol\/mol (6.5%\u20137.0%), and only 14% (i.e., 0.1% of the total study population) had HbA1c &gt;64\u00a0mmol\/mol (8.0%). Compared with normoglycaemic participants, those with undiagnosed diabetes or prediabetes had higher body mass index, waist circumference, systolic blood pressure, triglycerides and C\u2010reactive protein but lower low\u2010density lipoprotein cholesterol (all <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). Participants with undiagnosed diabetes had less favourable values for every measured risk factor compared with those with diagnosed diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The low prevalence of undiagnosed diabetes suggests that the current case\u2010finding\u2010based diagnostic practice is well\u2010functioning. Few participants with undiagnosed diabetes had very high HbA1c levels indicating severe hyperglycaemia. Nonetheless, participants with undiagnosed diabetes had a poorer cardiovascular risk profile compared with participants with known or no diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14829","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T08:08:05Z","timestamp":1647331685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population\u2010based study of 52,856 individuals. The HUNT Study, Norway"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7769-8780","authenticated-orcid":false,"given":"Vera Vik","family":"Bjark\u00f8","sequence":"first","affiliation":[{"name":"K.G. Jebsen Center for Genetic Epidemiology Department of Public Health and Nursing Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Clinic of Medicine St. Olavs Hospital Trondheim University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirin B.","family":"Haug","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Center for Genetic Epidemiology Department of Public Health and Nursing Norwegian University of Science and Technology  Trondheim Norway"},{"name":"MRC Integrative Epidemiology Unit Department of Population Health Sciences Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin P.","family":"S\u00f8rgjerd","sequence":"additional","affiliation":[{"name":"Clinic of Medicine St. Olavs Hospital Trondheim University Hospital  Trondheim Norway"},{"name":"HUNT Research Centre Department of Public Health and Nursing Norwegian University of Science and Technology  Levanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars C.","family":"Stene","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3404-2060","authenticated-orcid":false,"given":"Paz Lopez\u2010Doriga","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases Norwegian Institute of Public Health  Oslo Norway"},{"name":"Department of Endocrinology, Morbid Obesity and Preventive Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e5re I.","family":"Birkeland","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tore Julsrud","family":"Berg","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne L\u00f8vdal","family":"Gulseth","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein M.","family":"Iversen","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Sciences Western Norway University of Applied Sciences  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnulf","family":"Langhammer","sequence":"additional","affiliation":[{"name":"HUNT Research Centre Department of Public Health and Nursing Norwegian University of Science and Technology  Levanger Norway"},{"name":"Levanger Hospital Nord\u2010Tr\u00f8ndelag Hospital Trust  Levanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn Olav","family":"\u00c5svold","sequence":"additional","affiliation":[{"name":"K.G. 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