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NAFLD is a silent condition that may not become manifest until severe liver damage (fibrosis or cirrhosis) has occurred. Consequently, NAFLD and its complications often remain undiagnosed. Research evidence shows that NAFLD is extremely common and some estimates suggest that it occurs in up to 70% of people with T2DM. In the last 5\u2009years, it has become evident that NAFLD not only increases the risk of cirrhosis, primary liver cancer and end\u2010stage liver disease, but NAFLD is also an important multisystem disease that has major implications beyond the liver. NAFLD increases the risk of incident T2DM, cardiovascular disease, chronic kidney disease and certain extra\u2010hepatic cancers, and NAFLD and T2DM form part of a vicious spiral of worsening diseases, where one condition affects the other and vice versa. Diabetes markedly increases the risk of liver fibrosis and liver fibrosis is the most important risk factor for hepatocellular carcinoma. It is now possible to diagnose liver fibrosis with non\u2010invasive tools and therefore it is important to have clear care pathways for the management of NAFLD in patients with T2DM. This review summarises key recent research that was discussed as part of the Banting lecture at the annual scientific conference in 2022.<\/jats:p>","DOI":"10.1111\/dme.14912","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T13:45:43Z","timestamp":1657028743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Banting memorial lecture 2022: \u2018Type 2 diabetes and nonalcoholic fatty liver disease: Partners in crime\u2019"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-7753","authenticated-orcid":false,"given":"Christopher D.","family":"Byrne","sequence":"first","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism University Hospital Southampton and University of Southampton  Southampton 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