{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:16Z","timestamp":1788872296239,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004343","name":"Stavros Niarchos Foundation","doi-asserted-by":"publisher","award":["SNF32003B_176119"],"award-info":[{"award-number":["SNF32003B_176119"]}],"id":[{"id":"10.13039\/501100004343","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Gestational diabetes (GDM) presents an increased cardio\u2010metabolic risk and is diagnosed with an oral glucose tolerance test (OGTT). Reactive hypoglycaemia (RH) during the OGTT in pregnancy is associated with adverse outcomes. Although postpartum OGTT after GDM is recommended, the occurrence and implications of RH are unknown. We investigated the prevalence, metabolic implications and longitudinal evolution of RH at 6\u20138\u2009weeks postpartum in women with a history of GDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2011 and 2021, we consecutively followed 1237 women with previous GDM undergoing an OGTT at 6\u20138\u2009weeks postpartum. RH was defined as 2\u2010h glucose &lt;3.9\u2009mmoL\/L after the OGTT. Metabolic outcomes were compared in women with and without RH (RH+\/RH\u2212). We also included a subcohort of 191 women with data on insulin sensitivity\/secretion indices (MATSUDA, HOMA\u2010IR, insulin\u2010adjusted\u2010secretion ISSI\u20102).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The postpartum prevalence of RH was 12%. RH+ women had a more favourable metabolic profile including a 2\u20105\u2010times lower prevalence of glucose intolerance and metabolic syndrome at 6\u20138\u2009weeks postpartum compared to RH\u2212 (all <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.034). In the subcohort, women with RH+ had higher insulin sensitivity, higher ISSI\u20102 and an earlier glucose peak after OGTT (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.049) compared to RH\u2212 women at the same time point. Insulin resistance increased and ISSI\u20102 decreased over the first year postpartum in both groups. These changes were associated with a 50% reduction in overall RH prevalence at 1\u2010year postpartum. Some of the favourable profiles of RH+ persisted at 1\u2010year postpartum, without group differences in the longitudinal metabolic changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At 6\u20138\u2009weeks postpartum, RH was frequent in women after GDM and associated with a better metabolic profile including increased insulin sensitivity and higher insulin\u2010adjusted\u2010secretory capacity. RH might be a marker of favourable metabolic prognosis in women with a history of GDM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14920","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T18:09:55Z","timestamp":1658599795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reactive hypoglycaemia during the <scp>OGTT<\/scp> after gestational diabetes mellitus: Metabolic implications and evolution"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3091-9400","authenticated-orcid":false,"given":"Dan Yedu","family":"Quansah","sequence":"first","affiliation":[{"name":"Obstetric Service, Department Woman\u2010Mother\u2010Child Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"De Giorgi","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetes and Metabolism, Department of Medicine Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Le Dizes","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetes and Metabolism, Department of Medicine Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Camponovo","sequence":"additional","affiliation":[{"name":"Clinic for Endocrinology and Diabetology, Lugano Regional Hospital Ente Ospedaliero Cantonale (EOC)  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3325-0263","authenticated-orcid":false,"given":"Katrien","family":"Benhalima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology UZ Gasthuisberg, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-3385","authenticated-orcid":false,"given":"Emmanuel","family":"Cosson","sequence":"additional","affiliation":[{"name":"Department of Endocrinology\u2010Diabetology\u2010Nutrition, AP\u2010HP Avicenne Hospital, Paris 13 University, Sorbonne Paris Cit\u00e9, CRNH\u2010IdF, CINFO  Bobigny France"},{"name":"Sorbonne Paris Cit\u00e9 UMR U1153 Inserm\/U1125 Inra\/Cnam\/Universit\u00e9 Paris 13  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0460-7614","authenticated-orcid":false,"given":"Jardena J.","family":"Puder","sequence":"additional","affiliation":[{"name":"Obstetric Service, Department Woman\u2010Mother\u2010Child Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4840-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047320"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S002"},{"key":"e_1_2_10_5_1","unstructured":"National Insitute for Health and Care Excellence [NICE].National Institute for Health and Care Excellence (2015): Diabetes in pregnancy: management from preconception to the postnatal period (NG3). 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