{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:41:34Z","timestamp":1772185294218,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013806","name":"Wounds Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Diabetes\u2010related foot ulceration (DFU) is a common limb\u2010threatening condition, which is complex and subsequently challenging to manage. The aim of this study was to determine the contribution of a range of clinical and social factors to the healing of diabetes\u2010related foot ulceration in an Australian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research design and methods<\/jats:title><jats:p>This was a prospective cohort study of individuals with diabetes\u2010related foot ulceration (DFU). Age, sex, medical history, medications, dietary supplementation (e.g. vitamin C intake) and smoking history were elicited at baseline. The index of relative socio\u2010economic disadvantage (IRSD) was calculated. The Australian Eating Survey and International Physical Activity Questionnaire\u2010short were administered. Wound history, size, grade, time to healing and infection were captured and monitored over 6\u2009months. Logistic regression was performed to determine the relationship between healing and diet quality, toe systolic pressure, wound size at, IRSD, infection and previous amputation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 117 participants were included. The majority were male <jats:italic>n<\/jats:italic>\u00a0=\u200996 (82%), socio\u2010economically disadvantaged (mean IRSD 965, SD 60), and obese (BMI 36\u2009kg\/m<jats:sup>2<\/jats:sup>, SD 11) with a long history of diabetes (20\u2009years, SD 11). Wounds were predominantly neuropathic (<jats:italic>n<\/jats:italic>\u00a0=\u200985, 73%) and classified 1A (<jats:italic>n<\/jats:italic>\u00a0=\u200963, 54%) on the University of Texas wound classification system with few infections (<jats:italic>n<\/jats:italic>\u00a0=\u200923, 16%). Dietary supplementation was associated with 4.36 increased odds of healing (95% 1.28\u201314.84, <jats:italic>p<\/jats:italic>\u00a0=\u20090.02), and greater levels of socio\u2010economic advantage were also associated with increased odds of healing (OR 1.01, 95% CI 1.01\u20131.02, <jats:italic>p<\/jats:italic>\u00a0=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cohort study of predominantly neuropathic, non\u2010infected DFU, individuals who had greater levels of socio\u2010economic advantage had significantly greater odds of DFU healing. Diet quality was poor in most participants, with individuals taking supplementation significantly more likely to heal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14951","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T03:08:50Z","timestamp":1662088130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Factors influencing diabetes\u2010related foot ulcer healing in Australian adults: A prospective cohort study"],"prefix":"10.1111","volume":"40","author":[{"given":"Peta Ellen","family":"Tehan","sequence":"first","affiliation":[{"name":"Department of Surgery, School of Clinical Sciences, Faculty of Medicine, Nursing and Allied Health Monash University  Clayton Victoria Australia"},{"name":"School of Health Sciences, College of Health, Medicine and Wellbeing University of Newcastle  Callaghan New South Wales 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