{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:28:04Z","timestamp":1793035684613,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate the effect of gestational diabetes mellitus (GDM) treatment on medium\/long\u2010term outcomes both the mother and offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review on randomized clinical trials addressing specific treatment of women with GDM versus usual care and its impact on maternal and offspring outcomes at medium\/long\u2010term. MEDLINE, EMBASE and CENTRAL were searched from inception to 8 October 2021. Outcome variables: maternal (diabetes, metabolic syndrome, 12 secondary); offspring (diabetes, impaired fasting glucose, impaired glucose tolerance, high body mass index, 15 secondary). Risk of bias was assessed with Cochrane tool and aggregation performed with Revman 5.4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included five studies (1140 women, 767 offspring) with follow\u2010up ranging 4\u201316\u2009years after delivery. GDM treatment likely does not reduce risk of maternal diabetes (RR 1.00; [95% CI 0.82\u20131.23]) and may not reduce that of metabolic syndrome (RR 0.93; [95% CI 0.71\u20131.22]). We obtained very uncertain evidence that treatment may increase maternal HDL\u2010cholesterol. Findings showed that GDM treatment may not have an impact on infants' outcomes (RRs 0.79; [95% CI 0.39\u20131.69] for impaired fasting glucose; RR 0.91; [95% CI 0.74\u20131.12] for body mass index &gt;85th centile and 0.89; [95% CI 0.65\u20131.22] for body mass index &gt;95th centile respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With current evidence is uncertain if specific treatment of women with GDM has an impact on medium\/long\u2010term metabolic outcomes either in the mother or in the offspring. These results add evidence to the recommendation of systematically reevaluating mother and offspring after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Registration<\/jats:title><jats:p>OSF, DOI 10.17605\/OSF.IO\/KFN79<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14998","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T14:59:51Z","timestamp":1667487591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Impact of gestational diabetes mellitus treatment on medium\/long\u2010term outcomes after pregnancy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"Apolonia","family":"Garc\u00eda\u2010Patterson","sequence":"first","affiliation":[{"name":"Sant Pau Biomedical Research Institute (IIB Sant Pau)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Balsells","sequence":"additional","affiliation":[{"name":"Independent Investigator  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Sol\u00e0","sequence":"additional","affiliation":[{"name":"Sant Pau Biomedical Research Institute (IIB Sant Pau)  Barcelona Spain"},{"name":"Iberoamerican Cochrane Centre, Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignasi","family":"Gich","sequence":"additional","affiliation":[{"name":"Sant Pau Biomedical Research Institute (IIB Sant Pau)  Barcelona Spain"},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Departament de Farmacologia i Terap\u00e8utica Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5055-6814","authenticated-orcid":false,"given":"Rosa","family":"Corcoy","sequence":"additional","affiliation":[{"name":"Sant Pau Biomedical Research Institute (IIB Sant Pau)  Barcelona Spain"},{"name":"Servei d'Endocrinologia i Nutrici\u00f3 Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Departament de Medicina Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"CIBER Bioingenier\u00eda, Biomateriales y Nanotecnolog\u00eda (CIBER\u2010BBN), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","first-page":"B33","article-title":"The Toronto tri\u2010Hospital gestational diabetes project. 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