{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:14:22Z","timestamp":1791350062806,"version":"4.3.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Type 1 diabetes is associated with a substantially increased risk of impaired lung function, which may impair aerobic fitness. We therefore aimed to examine the ventilatory response during maximal exercise and the pulmonary diffusion capacity function at rest in individuals with uncomplicated type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 17 adults with type 1 diabetes free from micro\u2013macrovascular complications (glycated haemoglobin: 8.0\u2009\u00b1\u20091.3%), and 17 non\u2010diabetic adults, carefully matched to the type 1 diabetes group according to gender, age, level of physical activity and body composition, participated in our study. Lung function was assessed by spirometry and measurements of the combined diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO) at rest. Subjects performed a maximal exercise test during which the respiratory parameters were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At rest, DLCO (30.4\u2009\u00b1\u20096.1\u00a0ml\u2009min<jats:sup>\u22121<\/jats:sup>\u00a0mmHg<jats:sup>\u22121<\/jats:sup> vs. 31.4\u2009\u00b1 5.7\u00a0ml\u2009min<jats:sup>\u22121<\/jats:sup> mmHg<jats:sup>\u22121<\/jats:sup>, respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.2), its determinants Dm (membrane diffusion capacity) and Vc (pulmonary capillary volume) were comparable among type 1 diabetes and control groups, respectively. Nevertheless, spirometry parameters (forced vital capacity\u00a0=\u00a04.9\u2009\u00b1\u20091.0\u00a0L vs. 5.5\u2009\u00b1\u20091.0\u00a0L, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05; forced expiratory volume 1\u00a0=\u00a04.0\u2009\u00b1\u20090.7\u00a0L vs. 4.3\u2009\u00b1\u20090.7\u00a0L, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) were lower in individuals with type 1 diabetes, although in the predicted normal range. During exercise, ventilatory response to exercise was different between the two groups: tidal volume was lower in type 1 diabetes vs. individuals without diabetes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Type 1 diabetes showed a reduced VO<jats:sub>2max<\/jats:sub> (34.7\u2009\u00b1\u20096.8 vs. 37.9\u2009\u00b1\u20096.3, respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) in comparison to healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Individuals with uncomplicated type 1 diabetes display normal alveolar\u2010capillary diffusion capacity and at rest, while their forced vital capacity, tidal volumes and VO<jats:sub>2<\/jats:sub> are reduced during maximal exercise.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.15036","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T15:28:50Z","timestamp":1672500530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Respiratory function in uncomplicated type 1 diabetes: Blunted during exercise even though normal at rest!"],"prefix":"10.1111","volume":"40","author":[{"given":"Islem","family":"Jlali","sequence":"first","affiliation":[{"name":"Univ. Lille, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, ULR 7369 \u2010 URePSSS \u2010 Unit\u00e9 de Recherche Pluridisciplinaire Sport Sant\u00e9 Soci\u00e9t\u00e9  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Heyman","sequence":"additional","affiliation":[{"name":"Univ. Lille, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, ULR 7369 \u2010 URePSSS \u2010 Unit\u00e9 de Recherche Pluridisciplinaire Sport Sant\u00e9 Soci\u00e9t\u00e9  Lille France"},{"name":"Institut Universitaire de France (IUF)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Matran","sequence":"additional","affiliation":[{"name":"Department of Physiology EA 2689 &amp; IFR 22  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Marais","sequence":"additional","affiliation":[{"name":"Univ. Lille, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, ULR 7369 \u2010 URePSSS \u2010 Unit\u00e9 de Recherche Pluridisciplinaire Sport Sant\u00e9 Soci\u00e9t\u00e9  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Descatoire","sequence":"additional","affiliation":[{"name":"Regional Hospital Center of Roubaix  Roubaix France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Rabasa\u2010Lhoret","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"D\u00e9partement de Nutrition, Facult\u00e9 de M\u00e9dicine Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"D\u00e9partement des Sciences Biom\u00e9dicales, Facult\u00e9 de M\u00e9dicine Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Endocrinology Division Montreal Diabetes Research Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Division of Endocrinology McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Touil","sequence":"additional","affiliation":[{"name":"Pulmonology Department Taher Sfar Hospital  Mahdia Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Pawlak\u2010Chaouch","sequence":"additional","affiliation":[{"name":"Univ. Lille, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, ULR 7369 \u2010 URePSSS \u2010 Unit\u00e9 de Recherche Pluridisciplinaire Sport Sant\u00e9 Soci\u00e9t\u00e9  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mucci","sequence":"additional","affiliation":[{"name":"Univ. Lille, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, ULR 7369 \u2010 URePSSS \u2010 Unit\u00e9 de Recherche Pluridisciplinaire Sport Sant\u00e9 Soci\u00e9t\u00e9  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Department of Diabetology University Hospital, EA 4489  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Baquet","sequence":"additional","affiliation":[{"name":"Univ. Lille, Univ. Artois, Univ. 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