{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:17:55Z","timestamp":1791883075450,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most commercially available automated insulin delivery (AID) systems are not approved for pregnancy use. Information regarding use of the Tandem t:slim X2 insulin pump with Control\u2010IQ\u2122 technology in pregnancy is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This case series aimed to explore glycaemic and qualitative experiences of four early adopters of Control\u2010IQ technology in pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants used Control\u2010IQ technology in pregnancy and postpartum and consented to analysis of glycaemic data and semi\u2010structured interviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Case 1 began Control\u2010IQ technology at 10\u2009weeks gestation. Her pregnancy glucose time\u2010in\u2010range (3.5\u20137.8\u2009mmol\/L [63\u2013140\u2009mg\/dL]) increased from 58.7% to 73.3% by third trimester. Cases 2\u20134 began using Control\u2010IQ technology 0\u20132\u2009months preconception. Pregnancy time\u2010in\u2010range glucose increased from 73.4% to 78.7%, 78% to 83.6%, and 46.5% to 71.9% between first and third trimesters, respectively. A mid\u2010pregnancy decline in time\u2010in\u2010range glucose was observed in two of the four participants related to suboptimal pump setting adjustments and delays in sensor and infusion set replacement. No diabetic ketoacidosis or severe hypoglycaemia occurred. All participants reported reduced diabetes management burden and improved sleep with Control\u2010IQ technology use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early adopters of Control\u2010IQ technology safely used this system off\u2010label in pregnancy and reported reduced diabetes management burden and improved sleep. The largest glycaemic improvements were observed among those with the lowest pregnancy time\u2010in\u2010range glucose at the beginning of pregnancy. Participants with low pregnancy glucose time\u2010in\u2010range increased their time\u2010in\u2010range with Control\u2010IQ technology use and participants with high pregnancy glucose time\u2010in\u2010range maintained and increased their time\u2010in\u2010range with less diabetes management burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.15086","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T07:34:41Z","timestamp":1678952081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Real\u2010world use of Control\u2010<scp>IQ<\/scp>\u2122 technology automated insulin delivery in pregnancy: A case series with qualitative interviews"],"prefix":"10.1111","volume":"40","author":[{"given":"Xinye Serena","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy D.","family":"Dunlop","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5842-2722","authenticated-orcid":false,"given":"Julie A.","family":"McKeen","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-7584","authenticated-orcid":false,"given":"Denice S.","family":"Feig","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8911-8192","authenticated-orcid":false,"given":"Lois E.","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Calgary  Calgary Alberta Canada"},{"name":"Department of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCJD.2017.10.038"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/DIA.2021.0073"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30167-5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.K1310"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/DCI19-0028"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03604.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1633-z"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/DC11-1430"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1602494"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/DC17-2534"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/DIA.2018.0060\/ASSET\/IMAGES\/LARGE\/FIGURE1.JPEG"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/DMRR.3248"},{"key":"e_1_2_12_14_1","unstructured":"Tandem_Diabetes_Care_Inc.Quick Reference Sheets for the t:slim X2 insulin pump\u2014Support.support.tandemdiabetes.com.https:\/\/support.tandemdiabetes.com\/hc\/en\u2010us\/articles\/1500011447881\u2010Quick\u2010Reference\u2010Sheets\u2010for\u2010the\u2010t\u2010slim\u2010X2\u2010insulin\u2010pump. 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