{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:28:12Z","timestamp":1753878492850,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Changes in maternal serum C\u2010peptide have been described during pregnancy in women with Type 1 diabetes. We aimed to determine whether in these women, C\u2010peptide, as measured by the urinary C\u2010peptide creatinine ratio (UCPCR), display changes during the course of pregnancy and in the postpartum period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this longitudinal study including 26 women, UCPCR was measured in the first, second, and third trimester of pregnancy, and postpartum, using a high sensitivity two\u2010step chemiluminescent microparticle immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>UCPCR was detectable in 7\/26 (26.9%) participants in the first trimester, 10\/26 (38.4%) in the second trimester, and 18\/26 (69.2%) in the third trimester. Changes in UCPCR concentrations were observed throughout pregnancy, significantly increasing from first to third trimester. UCPCR concentration in the three trimesters was associated with a shorter duration of diabetes and in the third trimester also with first trimester UCPCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>UCPCR detects longitudinal changes during pregnancy in women with type 1 diabetes mellitus, more marked in those with shorter diabetes duration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.15154","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T15:28:37Z","timestamp":1685028517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnancy induces longitudinal changes in urinary C\u2010peptide creatinine ratio in women with type 1 diabetes"],"prefix":"10.1111","volume":"41","author":[{"given":"Lilian C.","family":"Mendoza","sequence":"first","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London  London UK"},{"name":"Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"CIBER Bioengineering, Biomaterials and Nanotechnology, Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Tashkova","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5055-6814","authenticated-orcid":false,"given":"Rosa","family":"Corcoy","sequence":"additional","affiliation":[{"name":"Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"CIBER Bioengineering, Biomaterials and Nanotechnology, Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Dornhorst","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051530"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1832"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-0028"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03747.x"},{"issue":"2001","key":"e_1_2_9_6_1","first-page":"21","article-title":"C\u2010peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta\u2010cell function: report of an ADA workshop, 21\u201022 October 2001","volume":"53","author":"Palmer JP","year":"2004","journal-title":"Diabetes"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12159"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.129312"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.26.1.30"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.10.4.487"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003193"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03428.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3067-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2016-000313"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","unstructured":"MarkoskaA MendozaLC ValaiyapathiR ThornC.Insulin sensitivity assessed using urine C peptide creatinine ratio (UCPCR) in pregnancy: cross\u2010sectional analysis of an English multiethnic cohort.2018;1\u20135.","DOI":"10.1136\/bmjopen-2017-020029"},{"key":"e_1_2_9_16_1","unstructured":"GardosiJ Gestation Network.Customised weight centile calculator. GROW v8.1 UK.http:\/\/www.gestation.net\/birthweight_centiles\/centile_object.htm"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03554-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-2114"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-2072"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.15154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T06:09:24Z","timestamp":1703830164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.15154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,26]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/dme.15154"],"URL":"https:\/\/doi.org\/10.1111\/dme.15154","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"type":"print","value":"0742-3071"},{"type":"electronic","value":"1464-5491"}],"subject":[],"published":{"date-parts":[[2023,6,26]]},"assertion":[{"value":"2022-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15154"}}