{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:08:14Z","timestamp":1785229694664,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T00:00:00Z","timestamp":1697328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the relationship of diabetes with pancreatic cancer incidence among African American and Whites of similar socio\u2010economic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Southern Community Cohort Study, we conducted a follow\u2010up during 2002\u20132015 of pancreatic cancer incidence of 73,378 mostly low\u2010income participants aged 40\u201379\u2009years; 15,913 reported diabetes at baseline. Multivariable Cox analysis controlling for sex, family history of pancreatic cancer, BMI, smoking status, alcohol consumption, education, income and other important covariates, and with age as the timescale was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally, 265 incident pancreatic cancer cases were observed. Pancreatic cancer risk was increased among those with diabetes (HR 1.54, CI 1.16\u20132.05), with similar increases among African Americans (HR 1.51, CI 1.08\u20132.11) and Whites (HR 1.78, CI 1.00\u20133.16). No trend in risk was observed for diabetes duration among those with diabetes, with HRs of 1.39 (0.91\u20132.11), 2.31 (1.51\u20133.54) and 1.23 (0.80\u20131.89) for &lt;5, 5\u20139 and 10+ years duration, respectively. African Americans were at increased risk of pancreatic cancer (HR\u2009=\u20091.40, 95% CI 1.05\u20131.87), which persisted after adjusting for diabetes (HR 1.36, CI 1.02\u20131.81). The effect sizes for other pancreatic cancer risk factors with pancreatic cancer were similar by diabetes status, although a stronger association with low BMI was evident among those with diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diabetes increases pancreatic cancer risk similarly among African Americans and Whites in this Southern U.S. cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.15234","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:08:50Z","timestamp":1696219730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diabetes and pancreatic cancer risk in a multiracial cohort"],"prefix":"10.1111","volume":"41","author":[{"given":"Rebecca B. N.","family":"Conway","sequence":"first","affiliation":[{"name":"American Academy of Epidemiology, Inc.  Tyler Texas USA"},{"name":"Department of Epidemiology University of Colorado School of Public Health, Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana G.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Public Health Strategies, LLC  South Charleston West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Munro","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fu","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan City Hubei Province P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald A.","family":"McClain","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Metabolism Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Blot","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,15]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Cancer Stat Facts: Pancreatic Cancer 2022. 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