{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:51:45Z","timestamp":1790607105968,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN\u2010143328"],"award-info":[{"award-number":["FDN\u2010143328"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The objective of this study was to determine whether the use of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) is associated with an increased risk of melanoma and nonmelanoma skin cancer, separately, compared with the use of sulfonylureas among patients with type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the United Kingdom Clinical Practice Research Datalink (2007\u20132019), we assembled two new\u2010user active comparator cohorts. In the first cohort assessing melanoma as the outcome, 11,786 new users of GLP\u20101 RAs were compared with 208,519 new users of sulfonylureas. In the second cohort assessing nonmelanoma skin cancer as the outcome, 11,774 new users of GLP\u20101 RAs were compared with 207,788 new users of sulfonylureas. Cox proportional hazards models weighted using propensity score fine stratification were fit to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of melanoma and nonmelanoma skin cancer, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with sulfonylureas, GLP\u20101 RAs were not associated with an increased risk of either melanoma (42.6 vs. 43.9 per 100,000 person\u2010years, respectively; HR 0.96, 95% CI 0.53\u20131.75) or nonmelanoma skin cancer (243.9 vs. 229.9 per 100,000 person\u2010years, respectively; HR 1.03, 95% CI 0.80\u20131.33). There was no evidence of an association between cumulative duration of use with either melanoma or nonmelanoma skin cancer. Consistent results were observed in secondary and sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this population\u2010based cohort study, GLP\u20101 RAs were not associated with an increased risk of melanoma or nonmelanoma skin cancer, compared with sulfonylureas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.15248","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T06:34:03Z","timestamp":1698215643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Glucagon like peptide\u20101 receptor agonists and the risk of skin cancer among patients with type 2 diabetes: Population\u2010based cohort study"],"prefix":"10.1111","volume":"41","author":[{"given":"Richeek","family":"Pradhan","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University  Montreal Quebec Canada"},{"name":"Centre for Clinical Epidemiology Jewish General Hospital, Lady Davis Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana H. 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