{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:01:09Z","timestamp":1787065269956,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type 1 diabetes mellitus (T1DM) is one of the most burdensome chronic diseases in the world. Health utility values are an important tool for quantifying this disease burden and conducting cost\u2010utility analyses. This review aimed to derive a reference set of health utility values for children and adolescents with T1DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched MEDLINE and Embase from inception to March 2023 for health utility values of T1DM children and adolescents (aged \u226418\u2009years) measured using direct and indirect preference elicitation approaches. Utility estimates were pooled by meta\u2010analyses with subgroup analyses to evaluate differences by populations and elicitation approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six studies involving 1276 participants were included in this study. Meta\u2010analysis showed the overall utility value of children and adolescents with T1DM was 0.91 (95% CI 0.89\u20130.93). The utility value of T1DM children and adolescents with complications was 0.90 (95% CI 0.88\u20130.92), which was lower than those without complications (0.96, 95% CI 0.95\u20130.97). The utility value of children (aged &lt;13\u2009years) was higher than adolescents (aged 13\u201318\u2009years) (0.90 vs. 0.85). The utility value measured by the EQ\u20105D\u20103L (0.91) was higher than the HUI3 (0.89), the SF\u20106Dv1 (0.83), and the time trade\u2010off (0.81). The parent proxy\u2010reported was similar to the patient self\u2010reported (0.91 vs. 0.91).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study developed a reference set of pooled utility estimates for children and adolescents with T1DM, which is helpful for understanding the overall health status of T1DM and conducting economic evaluations. Further studies are needed to explore the utilities of T1DM with different types of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.15251","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T02:26:27Z","timestamp":1698891987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Health state utility values for children and adolescents with type 1 diabetes: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"41","author":[{"given":"Shitong","family":"Xie","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science and Technology Tianjin University  Tianjin China"},{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Evidence\u2010based Medicine Center, School of Basic Medical Sciences Lanzhou University  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science and Technology Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science and Technology Tianjin University  Tianjin China"},{"name":"Center for Social Science Survey and Data Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science and Technology Tianjin University  Tianjin China"},{"name":"Center for Social Science Survey and Data Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehu","family":"Yang","sequence":"additional","affiliation":[{"name":"Evidence\u2010based Medicine Center, School of Basic Medical Sciences Lanzhou University  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6012-2785","authenticated-orcid":false,"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science and Technology Tianjin University  Tianjin China"},{"name":"Center for Social Science Survey and Data Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Diabetes in America","author":"Imperatore G","year":"2018"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.16"},{"key":"e_1_2_11_4_1","unstructured":"AtlasID.Type 1 Diabetes Estimates in Children and Adults 2022.https:\/\/diabetesatlas.org\/atlas\/t1d\u2010index\u20102022\/?dlmodal=active&dlsrc=https%3A%2F%2Fdiabetesatlas.org%2Fidfawp%2Fresource\u2010files%2F2022%2F12%2FIDF\u2010T1D\u2010Index\u2010Report.pdf."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18179245"},{"key":"e_1_2_11_8_1","volume-title":"Measuring and Valuing Health Benefits for Economic Evaluation","author":"Ratcliffe J","year":"2017"},{"key":"e_1_2_11_9_1","first-page":"24","article-title":"Health state utility values for type 2 diabetes and related complications in east and Southeast Asia: a systematic review and meta\u2010analysis","volume":"7","author":"Mok CH","year":"2021","journal-title":"Value in Health"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2015.00065"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2020.12.019"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S114699"},{"key":"e_1_2_11_13_1","volume-title":"NICE Decision Support Unit Technical Support Documents. 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