{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:46Z","timestamp":1753878646024,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>AimsWerner Syndrome is a rare premature ageing autosomal recessive disorder caused by pathogenic variants in the <jats:italic>WRN<\/jats:italic> gene. People with Werner Syndrome may develop diabetes mellitus. Chronic foot ulceration is seen, with some characteristics overlapping with diabetic foot disease. However, the clinical course of the ulceration is atypical of diabetic foot disease. We present four siblings from an Irish Traveller family with Werner Syndrome to highlight the complexity of this condition. The Irish Traveller population are an indigenous, endogamous population in which consanguinity is common. As a result, rare autosomal recessive disorders are prevalent among this population<\/jats:title><jats:p>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe our experience managing the complex foot disease seen in all four siblings. Foot complications present in the siblings include painful peripheral neuropathy, chronic foor ulceration, underlying osteomyelitis and acral melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cases are described individually, with a particular focus on the complex foot disease associated with the condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the siblings attend a diabetic foot clinic, we suggest that the combination of clinical features seen in these cases is unique to Werner syndrome and warrants the title \u2018Werner Syndrome\u2019 (rather than \u2018Diabetic\u2019) foot.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.15390","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T16:34:38Z","timestamp":1719246878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u2018Werner Syndrome foot\u2019\u2014A case series of four Irish Traveller siblings with Werner Syndrome, diabetes mellitus and complex foot disease"],"prefix":"10.1111","volume":"41","author":[{"given":"Aisling","family":"McGrath","sequence":"first","affiliation":[{"name":"Centre for Endocrinology, Diabetes and Metabolism Galway University Hospitals  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, Diabetes and Metabolism Galway University Hospitals  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-9394","authenticated-orcid":false,"given":"Tomas","family":"Griffin","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, Diabetes and Metabolism Galway University Hospitals  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally Ann","family":"Lynch","sequence":"additional","affiliation":[{"name":"Children's Health Ireland at Crumlin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean F.","family":"Dinneen","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, Diabetes and Metabolism Galway University Hospitals  Galway Ireland"},{"name":"University of Galway  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"National Organisation of Rare Diseases.Werner Syndrome. Accessed June 7 2023.https:\/\/rarediseases.org\/rare\u2010diseases\/werner\u2010syndrome\/"},{"key":"e_1_2_8_3_1","unstructured":"Central Statistics Office Census.2022Profile 5 \u2010 Diversity Migration Ethnicity Irish Travellers and Religion.www.cso.ie"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.14096"},{"volume-title":"Online Mendelian Inheritance in Man, OMIM\u00ae","year":"1986","author":"McKusick VA","key":"e_1_2_8_5_1"},{"key":"e_1_2_8_6_1","unstructured":"International Registry of Werner Syndrome. Accessed June 30 2023.https:\/\/www.orpha.net\/consor\/cgi\u2010bin\/OC_Exp.php?Lng=GB&Expert=902"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0562-0"},{"issue":"12","key":"e_1_2_8_8_1","first-page":"1239","article-title":"Evaluation of glucose tolerance and effect of dietary management on increased visceral fat in a patient with Werner syndrome","volume":"67","author":"Yamamoto R","year":"2020","journal-title":"J\u2010Stage"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.12.2094"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-010-0832-5"},{"issue":"1","key":"e_1_2_8_11_1","first-page":"P86","article-title":"Chronic leg ulcers in Werner's Syndrome","volume":"57","author":"Yeong EK","year":"2004","journal-title":"JPRAS"},{"issue":"6","key":"e_1_2_8_12_1","first-page":"176","article-title":"Traveller health: prevalence of diabetes, pre diabetes and the metabolic syndrome","volume":"102","author":"Tan S","year":"2009","journal-title":"Ir Med J"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2017-104974"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13688"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059709"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.15390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T15:42:47Z","timestamp":1728142967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.15390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/dme.15390"],"URL":"https:\/\/doi.org\/10.1111\/dme.15390","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"type":"print","value":"0742-3071"},{"type":"electronic","value":"1464-5491"}],"subject":[],"published":{"date-parts":[[2024,6,24]]},"assertion":[{"value":"2023-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15390"}}