{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:39:58Z","timestamp":1792035598480,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine risk factors for 1\u2010year postpartum weight retention (PPWR) and glucose intolerance (prediabetes\u2009+\u2009diabetes) in women with a previous history of gestational diabetes (GDM) and prediabetes in early postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this exploratory analysis of the MELINDA randomized controlled trial, we report data of 167 women with prediabetes at the 6\u201316\u2009weeks (early) postpartum oral glucose tolerance test after a recent history of GDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all participants, 45% (75) had PPWR &gt;0\u2009kg at 1\u2010year postpartum. Compared to women without PPWR, women with PPWR had higher gestational weight gain [10.5\u2009\u00b1\u20096.4 vs. 6.5\u2009\u00b1\u20094.5\u2009kg, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001], higher BMI (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and a worse metabolic profile (higher waist circumference, worse lipid profile and more insulin resistance) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) both in early and late postpartum. Of all women with PPWR, 40.0% developed metabolic syndrome, compared to 18.9% of women without late PPWR (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). The only independent predictor for late PPWR was weight retention in early postpartum (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Of all participants, 55.1% (92) had glucose intolerance (84 prediabetes, 8 diabetes) 1\u2010year postpartum. Independent predictors for late postpartum glucose intolerance were lower gestational age at start insulin therapy in pregnancy and delivery by caesarean section (resp. <jats:italic>p<\/jats:italic>\u2009=\u20090.044 and 0.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In women with a previous history of GDM and prediabetes in early postpartum, PPWR in early postpartum was a strong independent predictor for late PPWR, while earlier start of insulin therapy during pregnancy and delivery by caesarean section were independent predictors of glucose intolerance in late postpartum.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.15400","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T10:42:03Z","timestamp":1720003323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["One\u2010year postpartum weight retention and glucose intolerance in women with prediabetes after gestational diabetes"],"prefix":"10.1111","volume":"41","author":[{"given":"Val\u00e9rie","family":"Mievis","sequence":"first","affiliation":[{"name":"Faculty of Medicine KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caro","family":"Minschart","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Myngheer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology General Hospital Groeninge  Kortrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toon","family":"Maes","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Imelda Hospital  Bonheiden Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0679-3203","authenticated-orcid":false,"given":"Christophe","family":"de Block","sequence":"additional","affiliation":[{"name":"Department of Endocrinology\u2010Diabetology\u2010Metabolism Antwerp University Hospital  Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1265-9086","authenticated-orcid":false,"given":"Niels","family":"Bochanen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology\u2010Diabetology\u2010Metabolism Antwerp University Hospital  Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"van Pottelbergh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology OLV Hospital Aalst  Aalst Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Abrams","sequence":"additional","affiliation":[{"name":"Department of Endocrinology ZAS Sint\u2010Vincentius  Antwerp Belgium"},{"name":"Department of Endocrinology ZAS Sint\u2010Augustinus  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Vinck","sequence":"additional","affiliation":[{"name":"Department of Endocrinology ZAS Sint\u2010Augustinus  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Leuridan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology General Hospital Klina  Brasschaat Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabien","family":"Driessens","sequence":"additional","affiliation":[{"name":"Department of Endocrinology General Hospital Klina  Brasschaat Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaak","family":"Billen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Matthys","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospitals Leuven  Leuven Belgium"},{"name":"Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annouschka","family":"Laenen","sequence":"additional","affiliation":[{"name":"Centre of Biostatics and Statistical Bioinformatics KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Bogaerts","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration KU Leuven  Leuven Belgium"},{"name":"Faculty of Health University of Plymouth  Devon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospitals Leuven  Leuven Belgium"},{"name":"Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Benhalima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospitals Leuven  Leuven Belgium"},{"name":"Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7100351"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042973"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60731-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.05.004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2015.03.007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvad053"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2016.08.010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.3635"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108238"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102523"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082635"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2019.1637389"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01858.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-1009-0"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.9.1602"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02841.x"},{"issue":"226","key":"e_1_2_11_23_1","first-page":"1","article-title":"The Belgian Diabetes in Pregnancy Study (BEDIP\u2010N), a multi\u2010centric prospective cohort study on screening for diabetes in pregnancy and gestational diabetes: methodology and design","volume":"14","author":"Benhalima K","year":"2014","journal-title":"BMC Pregnancy Childbirth"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.12986"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-018-0517-0"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1527-x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31930-5"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12425"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10091891"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/798460"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac599"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3927-2"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.15400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T15:42:07Z","timestamp":1728142927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.15400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,3]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/dme.15400"],"URL":"https:\/\/doi.org\/10.1111\/dme.15400","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,3]]},"assertion":[{"value":"2024-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15400"}}