{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:16:30Z","timestamp":1790914590427,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Early post\u2010transplant hyperglycaemia (EPTH) and post\u2010transplant diabetes mellitus (PTDM) are common following solid organ transplantation and may be associated with adverse outcomes. We studied the prevalence of EPTH and cumulative 5\u2010year prevalence of PTDM in a modern cohort of heart transplant recipients who were free from diabetes at baseline as well as the association of EPTH, PTDM and pre\u2010transplant T2DM with adverse transplant\u2010related outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of heart transplant recipients followed for 5\u2009years at a single centre in Sydney, Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 141 patients were included, of whom 25 had pre\u2010existing type 2 diabetes mellitus (T2DM) and 116 were free from diabetes at baseline. In patients without pre\u2010existing T2DM, 88 of 116 (76%) experienced EPTH, which was associated with higher rates of acute rejection and hospitalizations, and lower 5\u2010year survival. PTDM developed in 45 of 116 (39%) patients, all of whom had experienced EPTH. Both PTDM and pre\u2010existing T2DM were associated with increased rates of graft rejection and hospitalization, and greater than three\u2010fold increased likelihood of death compared to patients that remained free from diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EPTH and PTDM are highly prevalent following cardiac transplantation. EPTH develops within days of transplant and is strongly associated with progression to PTDM. Pre\u2010existing T2DM, PTDM and EPTH are associated with greater hospitalization, increased episodes of rejection and worse 5\u2010year survival compared to patients who remained free from diabetes during follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.15441","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T04:33:22Z","timestamp":1727325202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of early post\u2010transplant hyperglycaemia and diabetes mellitus on outcomes following heart transplantation"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1430-0499","authenticated-orcid":false,"given":"Christopher A.","family":"Muir","sequence":"first","affiliation":[{"name":"School of Clinical Medicine Faculty of Medicine and Health UNSW  Sydney New South Wales Australia"},{"name":"Department of Endocrinology 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