{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:18:06Z","timestamp":1788315486850,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019168","name":"Starship Foundation","doi-asserted-by":"publisher","award":["A+8211"],"award-info":[{"award-number":["A+8211"]}],"id":[{"id":"10.13039\/501100019168","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate extension phase outcomes with intermittently scanned continuous glucose monitoring (isCGM 2.0) in children with type 1 diabetes mellitus (T1DM) and elevated HbA<jats:sub>1c<\/jats:sub> (7.5\u201312.2% [58\u2013110\u2009mmol\/mol]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred children with T1DM aged 4\u201313\u2009years were initially in a 12\u2010week randomised controlled trial (RCT) comparing glycaemic outcomes with isCGM 2.0 (intervention group, <jats:italic>n<\/jats:italic>\u2009=\u200949) with self\u2010monitored blood glucose (Control group, <jats:italic>n<\/jats:italic>\u2009=\u200951). After the 12\u2010week RCT both groups were offered an extension phase with isCGM 2.0 for another 12\u2009weeks. HbA<jats:sub>1c<\/jats:sub>, CGM metrics, psychological outcomes and device utilization attitudes were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the initial 12\u2010week RCT, 66 participants completed this 12\u2010week extension: 36\/49 (73%) and 30\/51 (58.8%) from the isCGM\/isCGM and Control\/isCGM groups, respectively. In the isCGM\/isCGM group, time below range 70\u2009mg\/dL (3.9\u2009mmol\/L) (TBR70) reduced from 10.7\u2009\u00b1\u200911.3% at baseline to 2.8\u2009\u00b1\u20092.8% and 2.1\u2009\u00b1\u20092.4% at 12 and 24\u2009weeks, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01 for both 12 and 24\u2009weeks). Glucose test frequency increased from 4.7 (2.7) at baseline to 10.7 (4.6) and 9.2 (4.7) at 12 and 24\u2009weeks, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01 for both 12 and 24\u2009weeks). The Control\/isCGM group decreased TBR70 from 10.7\u2009\u00b1\u20097.4% at 12\u2009weeks to 2.9\u2009\u00b1\u20092.8% at 24\u2009weeks and increased daily glucose test frequency from 3.2 (1.6) to 10.7 (5.4) from 12 to 24\u2009weeks (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). However, HbA<jats:sub>1c<\/jats:sub> and time in range (TIR) were non\u2010significant at 24\u2009weeks in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Extension phase outcomes with intermittently scanned continuous glucose monitoring (isCGM 2.0) in children with T1DM and elevated HbA<jats:sub>1c<\/jats:sub> showed a sustained reduction in hypoglycaemia and increased testing frequency at 24\u2009weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.15494","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T05:49:10Z","timestamp":1733896150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of Freestyle Libre 2.0 in children with type 1 diabetes mellitus and elevated <scp>HbA<sub>1c<\/sub><\/scp>: Extension phase results after a 12\u2010week randomized controlled trial"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0558-6712","authenticated-orcid":false,"given":"Yongwen","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health University of Otago  Dunedin New Zealand"},{"name":"The Third Affiliated Hospital of Sun Yat\u2010sen University Guangdong Provincial Key Laboratory of Diabetology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Otago  Dunedin New Zealand"},{"name":"Department of Pediatrics Te Whatu Ora Health New Zealand\u2014Southern  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Boucsein","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Styles","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronte","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Otago  Dunedin New Zealand"},{"name":"Department of Pediatrics Te Whatu Ora Health New Zealand\u2014Southern  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venus R.","family":"Michaels","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Otago  Dunedin New Zealand"},{"name":"Department of Pediatrics Te Whatu Ora Health New Zealand\u2014Southern  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamish R.","family":"Crockett","sequence":"additional","affiliation":[{"name":"Health, Sport and Human Performance, School of Health University of Waikato  Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Lala","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Te Whatu Ora Health New Zealand\u2014Hauora a Toi, Bay of Plenty New Zealand  Tauranga New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Te Whatu Ora Health New Zealand, Te Tai Tokerau  Whangarei New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esko J.","family":"Wiltshire","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Te Whatu Ora Health New Zealand\u2014Capital, Coast and Hutt Valley  Newtown New Zealand"},{"name":"Department of Pediatrics and Child Health University of Otago, Wellington  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-8351","authenticated-orcid":false,"given":"Anna S.","family":"Serlachius","sequence":"additional","affiliation":[{"name":"Psychological Medicine The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0541-6094","authenticated-orcid":false,"given":"Craig","family":"Jefferies","sequence":"additional","affiliation":[{"name":"Starship Child Health Te Whatu Ora\u2014Health New Zealand, Te Toka Tumai Auckland  Auckland New Zealand"},{"name":"Liggins Institute and Department of Pediatrics The University of Auckland  Auckland New 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