{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:07:48Z","timestamp":1789132068969,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002499","name":"International University of Korea","doi-asserted-by":"publisher","award":["10072163"],"award-info":[{"award-number":["10072163"]}],"id":[{"id":"10.13039\/501100002499","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The consequences of pre\u2010eclampsia (PE) are not limited to pregnancy; a single episode predisposes mothers to serious future health outcomes. Little is known about how PE impacts the course of type 2 diabetes (T2D) and associated microvascular diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Scottish Care Information for Diabetes data for individuals with diabetes in NHS Tayside and Fife was linked with Scottish maternity morbidity records. A nested case\u2013control study compared BMI, HDL cholesterol, systolic blood pressure(SBP) and HbA1c measures at T2D diagnosis between women with prior pregnancies from 1921 to 2022 affected or unaffected by PE using linear regression and adjusted for the other aforementioned variables. Cox regression models assessed how a PE history influenced the risk of future microvascular complications following T2D diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 6055 women were eligible: 726 (12%) had a PE\u2010pregnancy and 5329 (88%) had only PE\u2010free pregnancies, with ~20\u2009years between pregnancy and T2D diagnosis. At T2D diagnosis, women with a PE history had higher BMI (38.3\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      vs. 35.7\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), higher SBP (139\u2009mmHg vs. 135\u2009mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), lower HDL cholesterol (1.18\u2009mmol\/L vs. 1.21\u2009mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and were diagnosed 3.2\u2009years earlier (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A PE history was associated with increased microvascular disease risk (HR 1.26 95% CI 1.12\u20131.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001): diabetic retinopathy (HR 1.22 95% CI 1.07\u20131.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003); chronic kidney disease (HR 1.35 95% CI 1.06\u20131.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016); diabetic proteinuric kidney disease (HR 2.45 95% CI 1.03\u20135.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Women with a PE history were ~5\u2009years younger when they developed cardiovascular disease (55.7\u2009years vs. 60.6\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and all\u2010cause death (60.1\u2009years vs. 65.6\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>At T2D diagnosis, women with a PE history are younger, with more severe clinical presentations and increased risk of developing T2D microvascular complications. This highlights the crucial need for changes to the long\u2010term care of this high\u2010risk group, with aggressive risk\u2010factor management and continued clinical assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70046","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T15:25:20Z","timestamp":1747322720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical implications of a history of pre\u2010eclampsia in women with type two diabetes mellitus"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9104-9189","authenticated-orcid":false,"given":"Madeline C.","family":"Pearson","sequence":"first","affiliation":[{"name":"School of Medicine University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-819X","authenticated-orcid":false,"given":"Colin E.","family":"Murdoch","sequence":"additional","affiliation":[{"name":"School of Medicine University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6210-5620","authenticated-orcid":false,"given":"Alexander S. 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