{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:06:01Z","timestamp":1789707961338,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019168","name":"Starship Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019168","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009940","name":"Lotto New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009940","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The MiniMed\u2122 780G improves glycaemia and reduces burden in type 1 diabetes. We investigated how new all\u2010in\u2010one \u201cSimplera Sync\u2122\u201d sensors and 7\u2010day Extended\u2122 Wear Infusion Sets (EIS) affect glycaemia and system performance in young people with previously elevated HbA1c levels (\u226569\u2009mmol\/mol [\u22658%]) after transitioning from 780G with Guardian 4\u2122 sensors and 3\u2010day infusion sets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an extension phase analysis in 75 participants (aged 7\u201325\u2009years) initially enrolled in the CO\u2010PILOT randomised controlled trial. For this analysis, baseline was defined as the period following the use of 780G with Guardian 4\u2122 sensors and 3\u2010day infusion sets. Participants then transitioned to 780G with Simplera Sync\u2122 and EIS. We compared glycaemic and system performance outcomes from baseline to those after the transition to 780G with Simplera Sync\u2122 and EIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline HbA1c was 66.1\u2009mmol\/mol\u2009\u00b1\u200914.2\u2009mmol\/mol and remained stable at 66.7\u2009mmol\/mol\u2009\u00b1\u200911.2\u2009mmol\/mol after the transition (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.38). Time in range (3.9\u201310.0\u2009mmol\/L [70\u2013180\u2009mg\/dL]) at baseline was 58.5%\u2009\u00b1\u200914.9% and 60.4%\u2009\u00b1\u200915.7% after transition (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09). Time in tight range (3.9\u20137.8\u2009mmol\/L [70\u2013140\u2009mg\/dL]) increased from 38.1%\u2009\u00b1\u200913.1% at baseline to 40.5%\u2009\u00b1\u200913.6% after the transition (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). While using 780G with Simplera Sync\u2122 and EIS, automation time increased from baseline 79.2%\u2009\u00b1\u200925.9% to 85.8%\u2009\u00b1\u200921.8% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), and sensor wear time from 80.7%\u2009\u00b1\u200922.4% at baseline to 88.4%\u2009\u00b1\u200917.2% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Simplera Sync\u2122 and EIS improved time in automation and sensor wear time when using 780G AHCL in this high\u2010risk young population. This was associated with incremental improvement in time in tight range despite the challenges of this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70048","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T13:37:22Z","timestamp":1744983442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Simplera Sync\u2122 sensors and Extended\u2122 Wear Infusion Sets on glycaemia and system performance of the\n                    <scp>MiniMed<\/scp>\n                    \u2122\n                    <scp>780G<\/scp>\n                    system in children and young adults with previously high\n                    <scp>HbA1c<\/scp>"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5675-0339","authenticated-orcid":false,"given":"Venus R.","family":"Michaels","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-8802","authenticated-orcid":false,"given":"Alisa","family":"Boucsein","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0558-6712","authenticated-orcid":false,"given":"Yongwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health University of Otago  Dunedin New Zealand"},{"name":"Guangdong Provincial Key Laboratory of Diabetology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley D.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-3870","authenticated-orcid":false,"given":"Ryan G.","family":"Paul","sequence":"additional","affiliation":[{"name":"Te Huatakia Waiora School of Health University of Waikato  Hamilton New Zealand"},{"name":"Waikato Regional Diabetes Service Te Whatu Ora Waikato  Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8962-2708","authenticated-orcid":false,"given":"Esko","family":"Wiltshire","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health University of Otago  Wellington New Zealand"},{"name":"Department of Paediatrics and Child Health Te Whatu Ora Capital, Coast and Hutt Valley  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0541-6094","authenticated-orcid":false,"given":"Craig","family":"Jefferies","sequence":"additional","affiliation":[{"name":"Starship Child Health Te Whatu Ora Te Toka Tumai Auckland  Auckland New Zealand"},{"name":"Department of Paediatrics, Liggins Institute The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0454-6679","authenticated-orcid":false,"given":"Martin I.","family":"de Bock","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Otago  Christchurch New Zealand"},{"name":"Paediatric Endocriology Te Whatu Ora Health New Zealand Waitaha Canterbury  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-5238","authenticated-orcid":false,"given":"Benjamin J.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health University of Otago  Dunedin New Zealand"},{"name":"Paediatric Endocrinology Te Whatu Ora Health New Zealand Southern  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2400185"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0334"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1214975"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-2217"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-024-01397-4"},{"key":"e_1_2_13_7_1","volume-title":"NZDep2018 Index of Deprivation Final Research Report","author":"Atkinson 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Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dme.70048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:57:41Z","timestamp":1772996261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.70048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/dme.70048"],"URL":"https:\/\/doi.org\/10.1111\/dme.70048","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]},"assertion":[{"value":"2024-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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