{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:48:56Z","timestamp":1787604536969,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Approximately 40% of the caloric intake of the UK diet consists of starch. Most of which is readily digestible, thereby raising blood glucose. However, resistant starch (RS) evades metabolism in the small intestine, and in healthy adults, partial substitution of the diet with RS lowers postprandial glycaemia. The effect of RS in adults with type 2 diabetes is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the effect of substituting ~15% of dietary starch with RS on glycaemic measures in adults with type 2 diabetes in a controlled but free\u2010living setting. This was a single\u2010blinded, crossover design, comparing 4\u2010day RS and control diets. Proportions of resistant and digestible starch in identical food products were the only difference. IPro\u21222 continuous glucose monitors captured glycaemic excursions and glycaemic variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty adults with type 2 diabetes, HbA\n                      <jats:sub>1c<\/jats:sub>\n                      (52\u2009\u00b1\u20092\u2009mmol\/mol; 6.9\u2009\u00b1\u20090.3%), age 58\u2009\u00b1\u200911\u2009years, were enrolled, with 95% completing arms. Mean amplitude of glycaemic excursion (MAGE) was lower over lunch with RS (0.94\u2009mmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), as was SD glucose (0.31\u2009mmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027), and peak glucose (0.94\u2009mmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). RS prolonged the time it took glucose to peak by 18\u2009min at lunch (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046) and 28\u2009min at dinner (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Time in range (TIR; glucose 3.9\u201310.0\u2009mmol\/L) was 7.8% greater with RS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Substituting a proportion of starch with RS lowers blood glucose without changing the sensory attributes of foods significantly. There is potential to develop a functional diet for adults with type 2 diabetes to aid glycaemic control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70079","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T17:34:17Z","timestamp":1752082457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Partial starch substitution with resistant starch lowers postprandial glucose and glycaemic variability in people with type 2 diabetes"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8534","authenticated-orcid":false,"given":"Sineaid M.","family":"Collins","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bernadette Egan","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2897-2026","authenticated-orcid":false,"given":"Martin B.","family":"Whyte","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Denise Robertson","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.881"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1442"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/pop.2013.0099"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01011.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.117219"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4743"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-020-1417-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.987216"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508094658"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2395-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318424"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advnut.2023.06.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081833"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2011.2024"},{"key":"e_1_2_9_16_1","unstructured":"Nutrition S.A.C.o.SACN dietary reference values for energy. SACN: reports and position papers.2011."},{"key":"e_1_2_9_17_1","unstructured":"ISO sensory analysis\u2014methodology\u2014paired comparison test.2005."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nbu.12476"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2016.397"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60613-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317707293"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0199"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i3.432"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05474-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-00529-z"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1307-8"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-019-0086-9"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229680700100513"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1081-0"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111763"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R036012"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T17:32:16Z","timestamp":1755192736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/dme.70079"],"URL":"https:\/\/doi.org\/10.1111\/dme.70079","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"assertion":[{"value":"2024-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70079"}}