{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:51:42Z","timestamp":1773388302402,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To utilise Fremantle Diabetes Study Phase II (FDS2) data to examine the association between Type 2 diabetes and incident aortic valve replacement (AVR) and to investigate potential risk factors in Type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We followed 1430 FDS2 participants (mean age 66\u2009years, 53% males) and 5720 age\u2010, sex\u2010, and postcode\u2010matched people without diabetes from entry (2008\u20132011) to end\u20102021 for AVR ascertained from validated linked databases. Incidence rate ratios (IRRs) were calculated. Cox proportional hazards and competing risk models generated cause\u2010specific (cs) and subdistribution (sd) hazard ratios (HRs) for incident AVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, 11 participants with Type 2 diabetes (0.8%) and 37 without diabetes (0.6%) had undergone AVR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.589). There were 24 (1.7%) and 40 (0.7%) first incident AVR hospitalisations, respectively, in the two groups during 73,498 person\u2010years of follow\u2010up (IRR 2.40 [95% confidence interval (CI) 1.38, 4.08],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0007). In pooled analyses, Type 2 diabetes had similar csHR (2.38 [1.43, 3.96]) and sdHR (2.34 [1.41, 3.88]), with increasing age and male sex as other statistically significant covariates. In Type 2 diabetes, incident AVR was bivariably associated with baseline blood glucose\u2010lowering treatment intensity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and with distal symmetrical polyneuropathy (DSPN) after age and sex adjustment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Type 2 diabetes more than doubles the risk of AVR after adjusting for the competing risk of death. People with Type 2 diabetes going on to require AVR were more intensively managed and were more likely to have DSPN at baseline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70211","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T10:16:48Z","timestamp":1767608208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidence and associates of aortic valve replacement in people with or without type 2 diabetes: The Fremantle diabetes study phase\n                    <scp>II<\/scp>"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-7411","authenticated-orcid":false,"given":"Timothy M. E.","family":"Davis","sequence":"first","affiliation":[{"name":"Medical School The University of Western Australia, Fremantle Hospital  Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-8235","authenticated-orcid":false,"given":"Wendy A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Medical School The University of Western Australia, Fremantle Hospital  Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302265"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v2.i6.135"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.08.058"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092694"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.01.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1583267"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.03.099"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.08.015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0780-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.004580"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys065"},{"key":"e_1_2_10_14_1","unstructured":"Australian Bureau of Statistics.Socio\u2010Economic Indexes for Areas.2013. 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