{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:46:49Z","timestamp":1792212409934,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Asia faces a rising diabetes burden, with significant subregional variations. This study analyses trends from 1990 to 2021 and projects future burdens to guide targeted interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from the Global Burden of Disease Study 2021, we assessed type 2 diabetes cases, deaths, disability\u2010adjusted life\u2010years (DALYs) and age\u2010standardized rates across 35 Asian countries\/regions. Decomposition analysis identified burden drivers, and the Bayesian Age\u2010Period\u2010Cohort (BAPC) model predicted trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 1990 to 2021, Asia witnessed a substantial increase in the burden of type 2 diabetes, with Central Asia having the fastest\u2010growing age\u2010standardized incidence rate (ASIR) at estimated annual percentage change (EAPC) of 2.82. South Asia faced the heaviest burden, with 410,254 diabetes\u2010related deaths and 16,851,968 DALYs in 2021. The age\u2010standardized mortality rate (ASMR) was highest in Southeast Asia at 27.84 per 100,000. Key drivers included population growth, ageing and epidemiological changes, particularly in South Asia, with projections indicating continued increases in diabetes burden in South and Central Asia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Asia's diabetes burden has continued to increase, driven by population growth, ageing and epidemiological shifts. Targeted prevention, healthcare access and ageing policies are critical, especially in high\u2010burden regions like South and Central Asia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70216","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T06:31:48Z","timestamp":1767767508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Burden of type 2 diabetes in Asia\u2010Pacific regions, 1990\u20132021:\n                    <scp>GBD<\/scp>\n                    2021 analysis with forecast to 2050"],"prefix":"10.1111","volume":"43","author":[{"given":"Weimin","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Zhengzhou People's Hospital The Fifth Clinical Medical College of Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou China"},{"name":"Zhejiang Engineering Research Center for Intelligent Medical Imaging Sensing and Non\u2010Invasive Rapid Testing  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renfei","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghe","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou China"},{"name":"Zhejiang Engineering Research Center for Intelligent Medical Imaging Sensing and Non\u2010Invasive Rapid Testing  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5681-3663","authenticated-orcid":false,"given":"Yongpo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou China"},{"name":"Zhejiang Engineering Research Center for Intelligent Medical Imaging Sensing and Non\u2010Invasive Rapid Testing  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"IDF Diabetes Atlas","author":"Federation. 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