{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:00:22Z","timestamp":1790114422404,"version":"4.0.1"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","award":["PMAS\/21\/07"],"award-info":[{"award-number":["PMAS\/21\/07"]}],"id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore UK key\u2010opinion leader perspectives on the future role of stem cell\u2010derived islets (sc\u2010islets) in islet transplantation for people with type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four UK\u2010based key\u2010opinion leaders evaluated current limitations of donor islet transplantation and reviewed emerging evidence, clinical pathways and logistical considerations for sc\u2010islet transplantation, including alternative delivery sites and implications for kidney transplantation strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Conventional islet transplantation is constrained by donor scarcity, variable graft quality and lifelong immunosuppression, with associated risks of infection, malignancy and calcineurin inhibitor (CNI) nephrotoxicity. Stem cell\u2010derived islets, generated from human embryonic and induced pluripotent stem cells, provide a scalable and standardised alternative. Early investigational products, including Zimislecel (VX\u2010880), demonstrate potential for insulin independence and may offer an alternative to simultaneous pancreas\u2013kidney (SPK) transplantation. Strategies to reduce or eliminate systemic immunosuppression particularly CNI immunosuppression through local immunomodulation, gene editing and encapsulation technologies may further broaden access. Ethics, infrastructural and economic considerations remain central to equitable implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Stem cell\u2013derived islets may redefine islet transplantation for T1D by enabling more scalable, less invasive and sustainable therapeutic pathways while maintaining access to technological diabetes management options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70230","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:58:18Z","timestamp":1768971498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A\n                    <scp>UK<\/scp>\n                    key opinion leader perspective: Navigating the immunological and logistical transformation brought by stem cell\u2010derived islets for the treatment of type 1 diabetes"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7206-9172","authenticated-orcid":false,"given":"Thomas","family":"Strakosch","sequence":"first","affiliation":[{"name":"Cell and Gene Therapy Catapult (CGTC)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9127-0641","authenticated-orcid":false,"given":"Shareen","family":"Forbes","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science, Institute for Neuroscience and Cardiovascular Research, Queen's Medical Research Institute University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30078-0"},{"key":"e_1_2_18_3_1","unstructured":"NICE.Allogeneic pancreatic islet cell transplantation for type 1 diabetes mellitus. NICE interventional procedure guidance [IPG257].https:\/\/www.nice.org.uk\/guidance\/ipg2572008."},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000174"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02272.x"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2000.140201.x"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0090"},{"key":"e_1_2_18_8_1","unstructured":"Organ Donation Transplantation NR.2025.https:\/\/www.odt.nhs.uk\/transplantation\/pancreas\/."},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12093245"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2018.07.006"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.02.339"},{"key":"e_1_2_18_12_1","unstructured":"BTS.British Transplantation Society UK Guideline for the management of the patient with a failing kidney transplant.2023.https:\/\/bts.org.uk\/uk\u2010guideline\u2010for\u2010the\u2010management\u2010of\u2010the\u2010patient\u2010with\u2010a\u2010failing\u2010kidney\u2010transplant\/#SurgicalConsiderations"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znae163.683"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00241-9"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007273430401"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12469"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3554-3"},{"key":"e_1_2_18_18_1","unstructured":"NHS.NHS Blood and Transplant POL185\/7 \u2010 Pancreas Transplantation: Patient Selection 2025.https:\/\/nhsbtdbe.blob.core.windows.net\/umbraco\u2010assets\u2010corp\/37329\/pol185.pdf"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181e25a40"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-2688"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00310.2021"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16785"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00114-0"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2506549"},{"issue":"1","key":"e_1_2_18_25_1","first-page":"24","article-title":"The convergence of curative strategies: islet replacement, tolerance induction, and the path beyond immunosuppression in type 1 diabetes","volume":"13","author":"Forbes S","year":"2025","journal-title":"Eur Med J Diabetes"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2503822"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.02.001"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-025-00409-y"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00082-7"},{"key":"e_1_2_18_30_1","unstructured":"CITR.Scientific summary of the collaborative islet transplant registry (CITR) (11th) Annual Report 2022."},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.04.002"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636897231167323"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000864"},{"issue":"5","key":"e_1_2_18_34_1","article-title":"Subcutaneous clinical islet transplantation in a prevascularized subcutaneous pouch \u2013 preliminary experience","volume":"4","author":"Gala\u2010Lopez B","year":"2016","journal-title":"CellR4"},{"key":"e_1_2_18_35_1","unstructured":"Report CIT. Scientific summary of the collaborative islet transplant registry (CITR) 2023 (12th) allograft data Report 2025."},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102333"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1686"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0860-4"},{"key":"e_1_2_18_39_1","unstructured":"Organ Donation Transplantation.Living Donor Kidney Transplant.https:\/\/tinyurlcom\/yr5x2sn82025"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01923.x"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31819025e5"},{"key":"e_1_2_18_42_1","unstructured":"HeringB PosseltA NajiA et\u00a0al.Clinical Islet Transplantation Protocol CIT\u201006 NIDDK Central Repositary 2016.https:\/\/repository.niddk.nih.gov\/public\/study_document\/Documentation\/CIT\u201006\u2010_Islet_After_Kidney_Protocol_Version_8.0\u2010_November_30 _2016\u2010_CLEAN_VERSION.pdf"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32187-0"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00341-3"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000229384.22217.15"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14323"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.09.64"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14570"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01573.x"},{"key":"e_1_2_18_50_1","unstructured":"T1D B. In: Fung JaW P editor.2025https:\/\/www.breakthrought1d.org\/news\u2010and\u2010updates\/novel\u2010way\u2010to\u2010protect\u2010transplanted\u2010cells\u2010shows\u2010promise\/"},{"key":"e_1_2_18_51_1","unstructured":"Organ Donation Transplantation N.Proposed Kidney Offering Scheme and how this Impacts on SPK and SIK Patients. In: Group KOSW editor.https:\/\/tinyurlcom\/2uuh93bx20252025"},{"key":"e_1_2_18_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12159"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13807"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002158"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.03992.x"},{"key":"e_1_2_18_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0603-4"},{"key":"e_1_2_18_57_1","unstructured":"Vertex.VX\u2010264 update.2025.https:\/\/investorsvrtxcom\/news\u2010releases\/news\u2010release\u2010details\/vertex\u2010announces\u2010program\u2010updates\u2010type\u20101\u2010diabetes\u2010portfolio"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan5907"},{"key":"e_1_2_18_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00319-9"},{"key":"e_1_2_18_60_1","doi-asserted-by":"crossref","unstructured":"NICE.Hybrid closed loop systems for managing blood glucose levels in type 1 diabetes.2023.","DOI":"10.3310\/JYPL3536"},{"key":"e_1_2_18_61_1","volume-title":"Reduced progression of diabetic retinopathy in type 1 diabetes over three years with clinical islet transplantation or continuous subcutaneous insulin infusion compared with multiple daily insulin injections","author":"Reid L","year":"2019"},{"key":"e_1_2_18_62_1","article-title":"Adults with type 1 diabetes defining what matters in stem cell derived islet cell therapy","author":"Speight J","year":"2025","journal-title":"Nat Med"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dme.70230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:59:51Z","timestamp":1781326791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.70230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/dme.70230"],"URL":"https:\/\/doi.org\/10.1111\/dme.70230","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]},"assertion":[{"value":"2025-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70230"}}