{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:42:49Z","timestamp":1777934569808,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31702023"],"award-info":[{"award-number":["31702023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070440"],"award-info":[{"award-number":["32070440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170499"],"award-info":[{"award-number":["32170499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270513"],"award-info":[{"award-number":["32270513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2026,5]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n \n Epidemiological evidence suggests that atherosclerosis (AS) may precede or coexist with type 2 diabetes mellitus (T2DM); however, whether anti\u2010atherosclerotic interventions can reduce T2DM risk remains unclear. Chensinin\u20101b (C\u20101b), an antimicrobial peptide derived from the skin secretions of\n Rana chensinensis<\/jats:italic>\n , has previously demonstrated anti\u2010atherosclerotic activity, suggesting a potential therapeutic effect against T2DM in the context of AS.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In an apolipoprotein E\u2010knockout (\n ApoE<\/jats:italic>\n \n \u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n ) mice model induced by high\u2212fat diet (HFD), the developed process of pathological changes and inflammatory levels of pancreas and aorta were detected at early, middle and late stage of AS, meanwhile the anti\u2212atherosclerotic and anti\u2212diabetic effects of chensinin\u22121b were investigated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the early and middle stages of AS (6\u221210\u2009weeks), mice fasting blood glucose (FBG) did not change, but atherosclerotic symptoms were significantly exhibited, such as the increased pro\u2212inflammatory factors levels, aortic plaque and blood lipid levels. During the late stage of AS (14\u2009weeks), it was found that the FBG of\n ApoE<\/jats:italic>\n \n \u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n mice increased significantly, the pancreas was damaged, the insulin and blood lipid levels were unbalanced, and T2DM symptoms appeared. Treatment with chensinin\u22121b alleviated the progression of both AS and T2DM, particularly when it was administered in the early stage of the disease.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In\n ApoE<\/jats:italic>\n \n \u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n mice, prolonged atherosclerotic pathology is associated with T2DM development. The antimicrobial peptide chensinin\u22121b attenuates AS and improves metabolic parameters, indicating potential multitarget intervention capabilities. These findings identify chensinin\u22121b as a candidate molecule for preventing AS\u2212related metabolic abnormalities.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dme.70232","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:14:25Z","timestamp":1770873265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial peptide chensinin\u20101b attenuates\n T2DM<\/scp>\n progression in atherosclerotic\n ApoE<\/i>\n \n \u2212\/\u2212<\/i>\n <\/sup>\n mice"],"prefix":"10.1111","volume":"43","author":[{"given":"Zhongpeng","family":"Qiu","sequence":"first","affiliation":[{"name":"School of Life Science Liaoning Normal University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Life Science Liaoning Normal University Dalian 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