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I have focused the Banting Memorial Lecture 2025 on the implementation of national programmes across England since 2013, for which, along with colleagues at NHS England, I successfully made the case for investment, led the implementation of interventions applied at scale across the country and used routinely collected healthcare data to demonstrate clinical effectiveness in the real world. Through specific examples of implemented programmes, including the NHS Diabetes Prevention Programme and the NHS Type 2 Diabetes Path to Remission Programme, I highlight important fundamental principles when making the case for, and implementing, national policy. First, ensure granular data collection to support evaluation and exploit data linkages to harness the power of real\u2010world datasets. Second, where good evidence exists, implement evidence\u2010based policy; where good evidence does not exist but political pressures to implement are being brought to bear, pilot and evaluate. Third, when the opportunity arises, rapidly translate new high\u2010quality evidence into policy and practice. And fourth, support and protect the workload of healthcare professionals, particularly of those working in primary care. Then, through an epidemiological lens, I highlight: how the COVID\u201019 pandemic further unlocked the potential of national routinely collected electronic healthcare datasets; how, through application of these datasets, it has been possible to demonstrate improvements in diabetes complications and mortality through routine care delivery; and how it has been possible to demonstrate the next epidemiological transition in the global diabetes epidemic to multimorbidity\/multiple long\u2010term conditions.<\/jats:p>","DOI":"10.1111\/dme.70245","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T19:58:11Z","timestamp":1770667091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Banting memorial lecture 2025: Aligning clinical practice, policy and research"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-4061","authenticated-orcid":false,"given":"Jonathan","family":"Valabhji","sequence":"first","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Chelsea and Westminster Hospital Campus, Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.7208\/chicago\/9780226075631.001.0001"},{"issue":"232","key":"e_1_2_14_3_1","first-page":"763","article-title":"Improved survival of the diabetic foot: the role of a specialized foot clinic","volume":"60","author":"Edmonds ME","year":"1986","journal-title":"Q J Med"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0960"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03598.x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0848"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02828.x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03104.x"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4723-y"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06134-3"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.70028"},{"key":"e_1_2_14_12_1","unstructured":"NHS England.Five Year Forward View. 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