{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:43:58Z","timestamp":1777934638420,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the impact of diabetes on in\u2010hospital outcomes among patients with metabolic dysfunction\u2010associated steatotic liver disease (MASLD) who were hospitalized for cardiovascular disease (CVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cross\u2010sectional study using data from the nationwide Japanese Registry of All Cardiac and Vascular Diseases\u2010Diagnosis Procedure Combination, from April 2012 to March 2023. A total of 10,614 patients with MASLD hospitalized for CVD were identified, of whom 4550 (42.9%) had diabetes. The primary outcome was in\u2010hospital mortality, and secondary outcomes were major cardiac and non\u2010cardiac complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age was 66\u2009years, and 66.9% were male. Compared with patients without diabetes, those with diabetes had higher rates of ischaemic heart disease (35.5% vs. 30.8%), acute coronary syndrome (18.8% vs. 16.9%) and heart failure (27.3% vs. 25.4%) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In\u2010hospital mortality (5.6% vs. 3.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and overall complication rates (23.6% vs. 19.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were significantly greater in the diabetes group, driven mainly by cardiac events (16.8% vs. 10.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariable logistic regression confirmed diabetes as an independent predictor of in\u2010hospital mortality (odds ratio, 1.99; 95% confidence interval, 1.60\u20132.47;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diabetes was associated with higher in\u2010hospital mortality and complication rates among patients with MASLD hospitalized for CVD. Stratification of MASLD by metabolic phenotype, particularly in the presence of diabetes, may help improve risk assessment and inform more personalized clinical management in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70250","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T04:30:38Z","timestamp":1771216238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between diabetes and in\u2010hospital outcomes in patients with metabolic dysfunction\u2010associated steatotic liver disease hospitalized for cardiovascular disease: A nationwide database study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4946-2313","authenticated-orcid":false,"given":"Soichi","family":"Komaki","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michikazu","family":"Nakai","sequence":"additional","affiliation":[{"name":"Clinical Research Support Center University of Miyazaki Hospital  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-7284","authenticated-orcid":false,"given":"Yunosuke","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinuko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Komaki","sequence":"additional","affiliation":[{"name":"Divison of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Moribayashi","sequence":"additional","affiliation":[{"name":"Division 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kaikita","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2024.02.007"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2025.101898"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101271"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2023.0291"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16787"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003274"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02434-5"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2021.12.011"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00157-7"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003100"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.16016"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1253\/circrep.CR-21-0004"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30857"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0422"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2023.0004"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004517"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020804"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14502"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.15157"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001186"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001184"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02716-3"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.539528"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.05.012"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00314.2016"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.24671"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00308-3"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.156004"}],"container-title":["Diabetic 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