{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:16:14Z","timestamp":1790806574536,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>No randomised controlled trials have directly compared commercially available hybrid automated insulin delivery (AID) systems, and real\u2010world comparative data remain limited. This study evaluated glycaemic outcomes across three hybrid AID systems in adults with type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective, observational, single\u2010centre study and included adults with T1D who transitioned from multiple daily injections (MDI) or non\u2010automated insulin pump therapy to hybrid AID. Data were collected from routinely used clinical data\u2010sharing platforms and electronic health records. Outcomes compared across systems included time in range (TIR; 3.9\u201310.0\u2009mmol\/L), time below range (TBR; &lt;3.9 and &lt;3.0\u2009mmol\/L), time above range (TAR; &gt;10.0 and &gt;13.9\u2009mmol\/L), glucose management indicator (GMI, %) and coefficient of variation (CV, %).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 213 participants were included (Medtronic 780G\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938; Tandem Control\u2010IQ\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200981; Omnipod 5\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200994). After adjustment for baseline TIR, diabetes duration, insulin modality and AID use duration 780G users achieved a higher TIR increase (21.1% [95% CI 18.4\u201323.7]) compared to Control\u2010IQ (10.1% [3.2\u201317.3],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and Omnipod 5 (15.2% [12.9\u201317.5],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), with corresponding reductions in TAR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>All three hybrid AID systems were associated with improvements in glycaemic outcomes in real\u2010world use, supporting the role of AID systems in the management of T1D. Medtronic 780G use was associated with higher TIR increase compared with the other systems; however, these findings are based on measurements from different continuous glucose monitors between AID groups and cannot be used to infer superiority in glycaemic attainment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70251","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:05:40Z","timestamp":1770897940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Real\u2010world glycaemic outcomes observed with the use of Medtronic\n                    <scp>780G<\/scp>\n                    , Tandem Control\u2010\n                    <scp>IQ<\/scp>\n                    and Omnipod 5 automated insulin delivery systems"],"prefix":"10.1111","volume":"43","author":[{"given":"Muhammad S.","family":"Khan","sequence":"first","affiliation":[{"name":"Imperial College School of Medicine Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathana","family":"Sivanantham","sequence":"additional","affiliation":[{"name":"Imperial College School of Medicine Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanta","family":"Farouk","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeksha Reddy","family":"Lakshmareddy","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"},{"name":"School of Medicine Keele University  Keele Staffordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"De Scolasticis","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Cresta","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-465X","authenticated-orcid":false,"given":"Ian","family":"Godsland","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parizad","family":"Avari","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalantha","family":"Leelarathna","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6140-4493","authenticated-orcid":false,"given":"Monika","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-075681"},{"key":"e_1_2_11_3_1","unstructured":"NICE.Overview|Hybrid closed loop systems for managing blood glucose levels in type 1 diabetes|Guidance|NICE. Accessed December 19 2023.https:\/\/www.nice.org.uk\/guidance\/ta943."},{"key":"e_1_2_11_4_1","unstructured":"England NHS.NHS England \u00bb hybrid closed loop technologies: 5\u2010year implementation strategy. Accessed September 24 2025.https:\/\/www.england.nhs.uk\/long\u2010read\/hybrid\u2010closed\u2010loop\u2010technologies\u20105\u2010year\u2010implementation\u2010strategy\/."},{"key":"e_1_2_11_5_1","unstructured":"Medtronic Ypsomed Insulet HCL Algorithm SmartGuard Mylife Loop (Mylife CamAPS FX) SmartAdjust. Accessed September 18 2025.https:\/\/insulinsafetyweek.com\/wp\u2010content\/uploads\/2025\/04\/HCLV7130325.pdf."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2020.0546"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-2250"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2020.0572"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-1550"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.802419"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","unstructured":"SchiaffiniR DeodatiA NicolettiMC et\u00a0al.Comparison of two advanced hybrid closed loop in a pediatric population with type 1 diabetes: a real\u2010life observational study.2022;59(7):959\u2010964. doi:10.1007\/s00592-022-01886-z","DOI":"10.1007\/s00592-022-01886-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-1355"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15344"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1283181"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1600"},{"key":"e_1_2_11_16_1","unstructured":"Ministry of Housing Communities & Local Government.English Indices of Deprivation 2019. Accessed September 26 2019.https:\/\/www.gov.uk\/government\/statistics\/english\u2010indices\u2010of\u2010deprivation\u20102019."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaf006"},{"key":"e_1_2_11_18_1","unstructured":"Sheet Extracted from the SUPPORT Training Platform Produced by the BETTER Project. Accessed October 19 2025.https:\/\/type1better.com\/wp\u2010content\/uploads\/2022\/12\/Insulin\u2010pump\u2010comparison\u2010table.pdf."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-0129"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14433"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dme.70251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:27:23Z","timestamp":1777688843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.70251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/dme.70251"],"URL":"https:\/\/doi.org\/10.1111\/dme.70251","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"2025-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70251"}}