{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:57:54Z","timestamp":1781200674022,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n \n The study aimed to assess feasibility, acceptability and safety of an ILED in a randomised controlled trial of ILED vs. best NHS care healthy diet and exercise advice in women with Gestational Diabetes Mellitus (GDM) with body mass index \u226527.5\u2009kg\/m\n 2<\/jats:sup>\n (\u226525\u2009kg\/m\n 2<\/jats:sup>\n in high\u2010risk minority ethnic groups) in the last trimester of pregnancy.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Participants were randomised (1:1) to receive an ILED (1000\u2009kcal on two non\u2010consecutive days of the week with 5\u2009days\/week of best NHS care healthy diet and exercise advice) or best NHS care healthy diet and exercise advice 7\u2009days\/week from recruitment (24\u201330\u2009weeks gestation) until delivery (BNC). Primary outcomes were uptake, retention and adherence to the interventions. Maternal and neonatal safety outcomes were explored, and secondary outcomes assessed fidelity of the delivery of the intervention and completeness of study data across all trial participants.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Participants were randomised to ILED (\n n<\/jats:italic>\n \u2009=\u200914) or BNC (\n n<\/jats:italic>\n \u2009=\u200912) and 73% (\n n<\/jats:italic>\n \u2009=\u200919; ILED\n n<\/jats:italic>\n \u2009=\u200910, BNC\n n<\/jats:italic>\n \u2009=\u20099) received their allocated intervention. There was low study retention (58%; ILED\n n<\/jats:italic>\n \u2009=\u20097; BNC\n n<\/jats:italic>\n \u2009=\u20098) and low adherence to the ILED median (IQR) 37% (8%\u201350%) out of prescribed days; however, the study achieved a feasible uptake rate (31%;\n n<\/jats:italic>\n \u2009=\u200926). There were no adverse events specifically related to the ILED.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our findings suggest that ILED may not be feasible in the third trimester in people with GDM. Future research should explore alternative interventions and interventions earlier in pregnancy for the prevention and management of GDM.<\/jats:p>\n \n Trial registration number<\/jats:bold>\n : NCT05344066\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dme.70258","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:26:22Z","timestamp":1773998782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Testing the feasibility of an intermittent low\u2010energy diet in women with gestational diabetes"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-4514","authenticated-orcid":false,"given":"Elizabeth","family":"Dapre","sequence":"first","affiliation":[{"name":"Centre for Primary Care and Health Services Research The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Barrett","sequence":"additional","affiliation":[{"name":"Centre for Biostatistics The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-3877","authenticated-orcid":false,"given":"Brian","family":"McMillan","sequence":"additional","affiliation":[{"name":"Centre for Primary Care and Health Services Research The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pilkington","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahmy","family":"Hanna","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology University Hospitals of North Midlands NHS Trust Stoke\u2010on\u2010Trent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avni","family":"Vyas","sequence":"additional","affiliation":[{"name":"Faculty of Health and Education, Department of Health Professions Manchester Metropolitan University Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Lombardelli","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Womba","family":"Mubita","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology and Metabolic Services Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessy","family":"Athirampuzha","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology and Metabolic Services Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liveen","family":"Dosanjh","sequence":"additional","affiliation":[{"name":"School of Medical Sciences The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Harvie","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"},{"name":"Division of Cancer Sciences The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil G.","family":"Issa","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology and Metabolic Services Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Royal College of Obstetricians and Gynaecologists.Gestational Diabetes. 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