{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:57:57Z","timestamp":1781200677627,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Lifestyle modification, including caloric restriction and exercise, is fundamental in the treatment of people living with overweight and type 2 diabetes mellitus (T2D). The overall aim of lifestyle intervention schemes is to reduce body weight and improve glycaemic control to reduce the future risk of diabetes\u2010associated complications. The aim of this study is to determine whether intermittent energy restriction, exercise or their combination is best suited for reaching these targets in individuals with T2D not treated with insulin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized, controlled, monocentric parallel\u2010group trial is designed to investigate participants living with T2D, body mass index &gt;27\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , HbA1c \u226553\u2009mmol\/mol (\u22657.0%) and \u226486\u2009mmol\/mol (\u226410.0%) and without insulin therapy. Participants are equally and randomly allocated to one of four study groups: (1) intermittent energy restriction group, (2) exercise group, (3) combined intermittent energy restriction and exercise group and (4) control group. The intervention phase lasts 12\u2009weeks, followed by a two\u2010year follow\u2010up phase. In addition to assessing body weight and glycaemic parameters, resting energy expenditure (REE) and body composition are measured. An oral glucose tolerance test is carried out at baseline and at the end of the intervention. Additionally, stool samples for microbiome analyses and individual\u2010related outcomes are collected, and all participants are equipped with continuous glucose monitoring (CGM). The primary outcome measure is the change in bodyweight from baseline to day 84.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The study was registered at DRKS (Deutsches Register Klinischer Studien\u2014German Clinical Trial Register DRKS\u2010ID: DRKS00032036)\u2014Date of registration: 11.10.2023.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70328","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:20:18Z","timestamp":1776313218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and efficacy of intermittent fasting with or without exercise in people living with overweight or obesity and type 2 diabetes\u2014The\n                    <scp>INTERFAST<\/scp>\n                    \u20103 study design"],"prefix":"10.1111","volume":"43","author":[{"given":"Caren","family":"Sourij","sequence":"first","affiliation":[{"name":"Division of Cardiology Medical University of Graz  Graz Austria"},{"name":"Cardiometabolic Trials Unit, Division of Endocrinology and Diabetology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Cardiometabolic Trials Unit, Division of Endocrinology and Diabetology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Al\u2010Baghdadi","sequence":"additional","affiliation":[{"name":"Cardiometabolic Trials Unit, Division of Endocrinology and Diabetology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Aziz","sequence":"additional","affiliation":[{"name":"Cardiometabolic Trials 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