{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:11:23Z","timestamp":1789186283426,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015769","name":"Dexcom","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004166","name":"Warszawski Uniwersytet Medyczny","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate whether faster insulin aspart (FIA) improves time in range (TIR) compared with standard insulin aspart (SIA) in children and adolescents with type 1 diabetes achieving glycaemia close to target treated with continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, open\u2010label, randomized, 1:1 crossover trial included participants aged 6\u201317\u2009years with T1D duration of \u22651\u2009year, CSII use \u22653\u2009months, CGM use \u22651\u2009month, and HbA1c 64\u2009mmol\/mol (&lt;8%). After a 2\u2010week run\u2010in period, they then crossed over to the alternate insulin for another 4\u2009weeks. All participants used the same CGM system. Assessments were performed at the end of each treatment phase. The primary endpoint was the between\u2010treatment difference in TIR (3.9\u201310.0\u2009mmol\/L, 70\u2013180\u2009mg\/dL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010seven children were enrolled (mean T1D duration approximately 7\u2009years; 66% male; mean HbA1c 53\u2009mmol\/mol, 7%). Mean TIR was 68.5% (SD 12.3%) with SIA and 67.6% (SD 12.1%) with FIA, with no statistically significant difference (mean difference \u22120.9%; 95% CI \u20132.60 to 0.86;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.322). Similar patterns were observed for additional glycaemic metrics. Time in tight range was also similar between treatments: 46.3% for SIA versus 45.4% for FIA (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.674).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this randomised crossover study of children and adolescents with T1D achieving glycaemia close to target on CSII, switching from SIA to FIA does not improve TIR. The absence of improvement across CGM\u2010derived metrics suggests that FIA does not meaningfully enhance glycaemic outcomes in this clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70330","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T03:46:43Z","timestamp":1776052003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does faster aspart improve time in range in children with type 1 diabetes with glycaemia close to target on insulin pump therapy?"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0231-6784","authenticated-orcid":false,"given":"Kowalczyk\u2010Korcz","family":"Emilia","sequence":"first","affiliation":[{"name":"Department of Pediatric Diabetology and Pediatrics, The Children's Clinical Hospital Named After J.P. Brudzi\u0144ski University Clinical Center of the Warsaw Medical University  Warsaw Poland"},{"name":"Department of Diabetology and Pediatrics Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6295-2854","authenticated-orcid":false,"given":"Dymi\u0144ska","family":"Magdalena","sequence":"additional","affiliation":[{"name":"Department of Pediatric Diabetology and Pediatrics, The Children's Clinical Hospital Named After J.P. Brudzi\u0144ski University Clinical Center of the Warsaw Medical University  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4453-4381","authenticated-orcid":false,"given":"Groele","family":"Lidia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Diabetology and Pediatrics, The Children's Clinical Hospital Named After J.P. Brudzi\u0144ski University Clinical Center of the Warsaw Medical University  Warsaw Poland"},{"name":"Department of Diabetology and Pediatrics Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-3174","authenticated-orcid":false,"given":"Szypowska","family":"Agnieszka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Diabetology and Pediatrics, The Children's Clinical Hospital Named After J.P. Brudzi\u0144ski University Clinical Center of the Warsaw Medical University  Warsaw Poland"},{"name":"Department of Diabetology and Pediatrics Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-019-00685-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12506"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-016-0473-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163316"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0350"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14515"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-017-0514-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00834-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13963"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13205"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4378"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2020.0618"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296818822496"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2023.108587"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0042"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16326"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13610"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0895"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-023-01444-y"},{"key":"e_1_2_9_22_1","first-page":"1","article-title":"Impact of fast\u2010acting insulin aspart on glycaemic control in patients with type 1 diabetes using intermittent\u2010scanning continuous glucose monitoring within a real\u2010world setting: the GoBolus study","volume":"22","author":"Danne T","year":"2020","journal-title":"Diabetes Technol Ther"},{"key":"e_1_2_9_23_1","article-title":"Faster insulin aspart for continuous subcutaneous insulin infusion: is it worth it?","volume":"14","author":"Rosinha P","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-021-01165-0"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16268"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-0814"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0178"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16211"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0009"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2022.0468"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231204584"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dme.70330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:00:26Z","timestamp":1789185626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.70330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,12]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/dme.70330"],"URL":"https:\/\/doi.org\/10.1111\/dme.70330","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,12]]},"assertion":[{"value":"2026-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70330"}}