{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:31:08Z","timestamp":1786645868681,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type 1 diabetes (T1D) is a common disease. Although genome\u2010wide association studies (GWASs) have identified hundreds of associated single nucleotide polymorphisms (SNPs), very few T1D GWAS have simultaneously addressed both Asian and European populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we conducted a large\u2010scale trans\u2010ancestry meta\u2010analysis including 680,539 European individuals (12,525 T1D cases and 668,014 controls) and 133,251 Asian individuals (1,219 T1D cases and 132,032 controls) to identify genetic associations with T1D. Subsequently, fine\u2010mapping and Summary\u2010data\u2010based Mendelian randomization (SMR) analyses were performed to further refine T1D\u2010related genetic signals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 27 T1D\u2010associated loci, including 8 potentially novel loci (near\n                      <jats:italic>CDKAL1<\/jats:italic>\n                      ,\n                      <jats:italic>NRSN1<\/jats:italic>\n                      ,\n                      <jats:italic>FAM65B<\/jats:italic>\n                      ,\n                      <jats:italic>LRRC16A<\/jats:italic>\n                      ,\n                      <jats:italic>TULP1<\/jats:italic>\n                      ,\n                      <jats:italic>SLC17A3<\/jats:italic>\n                      ,\n                      <jats:italic>LRIG2<\/jats:italic>\n                      ,\n                      <jats:italic>C6orf1<\/jats:italic>\n                      ). Fine\u2010mapping was performed and helped pinpoint 7 putative causal variants (posterior probability, PP\u2009&gt;\u20090.95) with T1D. Among them, rs9366622 (PP\u2009=\u20090.976) and rs1165190 (PP\u2009=\u20090.996) are located near\n                      <jats:italic>LRRC16A<\/jats:italic>\n                      and\n                      <jats:italic>SLC17A3<\/jats:italic>\n                      , respectively.\n                    <\/jats:p>\n                    <jats:p>\n                      These two variants are the lead SNPs of identified novel loci. SMR analysis identified a putative risk gene (\n                      <jats:italic>U91328.19<\/jats:italic>\n                      ) at the novel locus\n                      <jats:italic>SLC17A3<\/jats:italic>\n                      \u2010rs1165190, whose expression level is causally associated with T1D.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that, for T1D, increasing ancestral diversity in genetic studies helps identify core genes and provides new insights into pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70434","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T17:51:36Z","timestamp":1786643496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trans\u2010ancestry meta\u2010analysis of genome\u2010wide association study identifies eight novel genetic loci in type 1 diabetes: A multi\u2010population study"],"prefix":"10.1111","author":[{"given":"Xuying","family":"Guo","sequence":"first","affiliation":[{"name":"College of Bioinformatics Science and Technology Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyang","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanwu","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology Harbin Medical University  Harbin 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