{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:50:41Z","timestamp":1791366641879,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The study investigated diabetes overtreatment (excessively intensive therapy) and flags for considering deprescribing glucose\u2010lowering treatment (GLT) (clinical features identifying patients most likely to benefit from reducing treatment) in older adults with type 2 diabetes (T2D) and their association with five\u2010year survival in geriatric inpatients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010centre retrospective cohort study including geriatric inpatients hospitalised between 2008 and 2015, aged \u226575\u2009years with T2D on GLT. Diabetes overtreatment, according to the 2019\u2010Endocrine Society guidelines, was retrospectively defined based on the patient's health status, level of HbA1c and presence of inducing hypoglycaemia GLT. Flags for deprescribing were selected from a systematic review of recommendations for GLT deprescribing in older diabetic adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 447 inpatients (women: 52.8%; median age: 83\u2009years), 89% had a poor health status, 55.2% were overtreated, and 99.5% had at least one deprescribing flag, and 44% of patients with \u22651 deprescribing flag were not overtreated. Over the five\u2010year follow\u2010up, median survival time after hospitalisation was 1.83\u2009years [IQR, 1.56\u20132.09], with an 18% five\u2010year survival [95%CI, 15%\u201322%]. Both overtreatment (HR [95%CI] 1.29 [1.04;1.58]) and accumulation of flags for deprescribing (HR [95%CI] 1.20 [1.11;1.29] per additional flag) were associated with increased mortality. Patients meeting both \u22654 flags for deprescribing and overtreated had the worst survival outcomes (10% five\u2010year survival rate).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The cumulative burden of deprescribing flags provided complementary information beyond the current overtreatment definition. Patients classified as overtreated and combining several deprescribing criteria highlight a particularly vulnerable subgroup of patients with poor survival in which GLT use should be systematically reassessed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70435","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:33:25Z","timestamp":1784781205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diabetes overtreatment and flags for deprescribing glucose\u2010lowering treatment in geriatric inpatients with type 2 diabetes: Prognostic insights from a longitudinal cohort"],"prefix":"10.1111","volume":"43","author":[{"given":"Christophe","family":"de Terwangne","sequence":"first","affiliation":[{"name":"Institut de Recherche Experimentale et Clinique, Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Division of Geriatric Medicine Cliniques 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