{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:01:20Z","timestamp":1790679680071,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate global caregivers' knowledge, perceptions and willingness to consider disease\u2010modifying therapies for the prevention of clinical onset of type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An online survey was translated into 13 languages and disseminated worldwide from June 2024 to February 2025 to parents and caregivers of youth living with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1281 respondents from 50 countries, awareness of available disease\u2010modifying therapies was low, while the perceived importance of delaying clinical disease onset was high. Reflecting this limited knowledge, only 31% expressed unconditional willingness to accept disease\u2010modifying treatments. Willingness to accept treatment was associated with higher educational attainment, residence in high\u2010income countries and prior knowledge of these therapies. Safety concerns, route of administration and limited information were major barriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Informational and socioeconomic barriers to caregivers' awareness and acceptance of disease\u2010modifying therapies may hinder the equitable implementation of preventive immunotherapy, highlighting the need for accessible, multilingual education initiatives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.70478","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:36:43Z","timestamp":1790678203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Awareness drives willingness: Results of the\n                    <scp>ISPAD JENIOUS<\/scp>\n                    \u2014\n                    <scp>PREME T1D<\/scp>\n                    project on parents' perspectives on disease\u2010modifying therapy in\n                    <scp>T1D<\/scp>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4369-7798","authenticated-orcid":false,"given":"Stefano","family":"Passanisi","sequence":"first","affiliation":[{"name":"Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5168-8317","authenticated-orcid":false,"given":"Claudia","family":"Piona","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes and Metabolic Disorders Unit, Regional Center for Pediatric Diabetes University City Hospital  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-4433","authenticated-orcid":false,"given":"Agata","family":"Chobot","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Medical Sciences University of Opole  Opole Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cudizio","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics Santa Casa of S\u00e3o Paulo School of Medical Sciences  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apoorva","family":"Gomber","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"Hauck","sequence":"additional","affiliation":[{"name":"#dedoc\u00b0 Diabetes Online Community  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bauer","sequence":"additional","affiliation":[{"name":"#dedoc\u00b0 Diabetes Online Community  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Alvarez Pagola","sequence":"additional","affiliation":[{"name":"#dedoc\u00b0 Diabetes Online Community  Berlin Germany"},{"name":"Innodia.org  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Innodia.org  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"DiMeglio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ISPAD Jenious Group Collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"10511","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/S0140-6736(25)01438-2","article-title":"The future of type 1 diabetes therapy","volume":"406","author":"Ziegler AG","year":"2025","journal-title":"Lancet"},{"issue":"7","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJMoa1902226","article-title":"An anti\u2010CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes","volume":"381","author":"Herold KC","year":"2019","journal-title":"N Engl J Med"},{"issue":"583","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc8980","article-title":"Teplizumab improves and stabilizes beta cell function in antibody\u2010positive high\u2010risk individuals","volume":"13","author":"Sims 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LM","year":"2025","journal-title":"Diabetes Obes Metab"},{"issue":"5","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1111\/dom.16246","article-title":"Real\u2010world experiences of adult individuals or caregivers of children who received teplizumab treatment in stage 2 type 1 diabetes","volume":"27","author":"O'Donnell HK","year":"2025","journal-title":"Diabetes Obes Metab"},{"issue":"6","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","DOI":"10.1111\/dme.15329","article-title":"Are we ready to screen for type 1 diabetes? A structured worldwide survey among healthcare providers involved in paediatric diabetes care","volume":"41","author":"Neuman V","year":"2024","journal-title":"Diabet Med"},{"issue":"2","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2337\/dc20-0927","article-title":"Parent and pediatrician preferences for type 1 diabetes screening in the U.S","volume":"44","author":"Dunne JL","year":"2021","journal-title":"Diabetes Care"},{"issue":"6","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00125-025-06408-4","article-title":"The efficacy of islet autoantibody screening with or without genetic pre\u2010screening strategies for the identification of presymptomatic type 1 diabetes","volume":"68","author":"Bonifacio E","year":"2025","journal-title":"Diabetologia"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dme.70478","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:36:44Z","timestamp":1790678204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.70478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":10,"alternative-id":["10.1111\/dme.70478"],"URL":"https:\/\/doi.org\/10.1111\/dme.70478","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70478"}}