{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:22:48Z","timestamp":1791285768993,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    No clinical studies on the lipolytic effect of guanine nucleotide\u2010binding protein \u03b23 subunit gene (\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GNB3<\/jats:styled-content>\n                    <\/jats:italic>\n                    )\n                    <jats:styled-content style=\"fixed-case\">825T<\/jats:styled-content>\n                    polymorphism have been performed. This study was a subinvestigation of a 12\u2010week randomized controlled trial (\n                    <jats:styled-content style=\"fixed-case\">NCT01184560<\/jats:styled-content>\n                    ) for the additive effect of orlistat on sibutramine treatment. The analysis involved 101 obese females aged 18\u201349 years, genotyped at the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GNB3<\/jats:styled-content>\n                    <\/jats:italic>\n                    825 locus. To exclude any influence from potential confounders, we used an analysis of covariance model. After the intervention, fat mass proportion in total weight loss was significantly lower in subjects with a T allele than in those without a T allele (p\u2009=\u20090.034).\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GNB3<\/jats:styled-content>\n                    <\/jats:italic>\n                    <jats:styled-content style=\"fixed-case\">825T<\/jats:styled-content>\n                    allele was associated with blunted fat mass reduction in obese females.\n                  <\/jats:p>","DOI":"10.1111\/dom.12023","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T05:30:10Z","timestamp":1350279010000},"page":"284-286","source":"Crossref","is-referenced-by-count":13,"title":["Effect of the G\u2010protein \u03b23 subunit\n                    <scp>825T<\/scp>\n                    allele on the change of body adiposity in obese female"],"prefix":"10.1111","volume":"15","author":[{"given":"I. C.","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Family Medicine Gachon University Gil Hospital  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Gachon University Gil Hospital  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Y.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Statistics Dongguk University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Gachon University Gil Hospital  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. W.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Dongguk University Ilsan Hospital  Goyang\u2010Si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.69"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021521"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1478"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90407-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-34786"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1601"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803499"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2472"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402078"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800875"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801925"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440360220035"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12023","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:23:39Z","timestamp":1761863019000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,8]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/dom.12023"],"URL":"https:\/\/doi.org\/10.1111\/dom.12023","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,8]]}}}