{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:34Z","timestamp":1791355954146,"version":"4.3.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2013,5]]},"abstract":"\n Glucagon\u2010like peptide\u20101 (\n GLP<\/jats:styled-content>\n \u20101) and peptide\n YY<\/jats:styled-content>\n (\n PYY<\/jats:styled-content>\n ), secreted by enteroendocrine L\u2010cells located most densely in the colon and rectum, are of fundamental importance in blood glucose and appetite regulation. In animal models, colonic administration of bile acids can stimulate\n GLP<\/jats:styled-content>\n \u20101 and\n PYY<\/jats:styled-content>\n by\n TGR5<\/jats:styled-content>\n receptor activation. We evaluated the effects of taurocholic acid (\n TCA<\/jats:styled-content>\n ), administered as an enema, on plasma\n GLP<\/jats:styled-content>\n \u20101 and\n PYY<\/jats:styled-content>\n , as well as gastrointestinal sensations in 10 healthy male subjects, and observed that rectal administration of\n TCA<\/jats:styled-content>\n promptly stimulated secretion of both\n GLP<\/jats:styled-content>\n \u20101 and\n PYY<\/jats:styled-content>\n , and increased fullness, in a dose\u2010dependent manner. These observations confirm that topical application of bile acids to the distal gut may have potential for the management of type 2 diabetes and obesity.\n <\/jats:p>","DOI":"10.1111\/dom.12043","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T23:48:30Z","timestamp":1353973710000},"page":"474-477","source":"Crossref","is-referenced-by-count":119,"title":["Effects of rectal administration of taurocholic acid on glucagon\u2010like peptide\u20101 and peptide\n YY<\/scp>\n secretion in healthy humans"],"prefix":"10.1111","volume":"15","author":[{"given":"T.","family":"Wu","sequence":"first","affiliation":[{"name":"Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Bound","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. D.","family":"Standfield","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gedulin","sequence":"additional","affiliation":[{"name":"Satiogen Pharmaceuticals Inc. San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Rayner","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia"},{"name":"Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01464.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.3.8355"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01554.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2009.07.013"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209706200"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.08.001"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm7015864"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199107000-00009"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2593-2"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601768"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.9.1219"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1948-8"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04139.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01772.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109100"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12043","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:00:06Z","timestamp":1761879606000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,17]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/dom.12043"],"URL":"https:\/\/doi.org\/10.1111\/dom.12043","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,17]]}}}