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Both fasting plasma glucose and postprandial glucose contribute to hemoglobin A1C levels. Addressing postprandial glucose levels can be accomplished by several approaches. Traditionally this has meant moving to basal bolus insulin, which is considered the gold standard. Premixed insulin may also be used. Data is also emerging for basal \u201cplus\u201d strategies, that is, incremental addition of prandial insulin injections. Newer approaches also reviewed in this article included premixed formulations containing ultra\u2010long acting basal insulin with rapid\u2010acting insulin analogs, inhaled insulin and insulin jet injectors, as well as the use of incretin\u2010based therapies.<\/jats:p>","DOI":"10.1111\/dom.12067","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T22:59:28Z","timestamp":1362178768000},"page":"11-17","source":"Crossref","is-referenced-by-count":6,"title":["Methods to enhance delivery of prandial insulin and basal\u2010prandial insulin"],"prefix":"10.1111","volume":"15","author":[{"given":"A. 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Newerinsulin analogs: advances in basal insulin replacement. Diabetes Obesity Metabolism 2012; in press.","DOI":"10.1111\/dom.12068"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2503"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1905"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0293e"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681200600406"},{"key":"e_1_2_8_31_1","unstructured":"Garg SK Kelly WC Freson BJ Petrucci RE Ritchie PJ. Treat\u2010to\u2010target Technosphere\u00aeinsulin in patients with type 1 diabetes. American Diabetes Association 71st Annual Scientific Sessions. June 24\u201328 2011; San Diego CA. 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