{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:32:06Z","timestamp":1761863526824,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,24]],"date-time":"2013-02-24T00:00:00Z","timestamp":1361664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2013,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n \n Visceral adipose tissue (\n VAT<\/jats:styled-content>\n ) and liver fat (\n LF<\/jats:styled-content>\n ) are strongly associated with type 2 diabetes. It is not known, however, how diabetes treatment and\/or risk factor management modulates the association between\n VAT<\/jats:styled-content>\n ,\n LF<\/jats:styled-content>\n and diabetes. The aim was to determine the level of\n VAT<\/jats:styled-content>\n and\n LF<\/jats:styled-content>\n in patients with type 2 diabetes according to their treatment status and achievement of the American Diabetes Association's (\n ADA<\/jats:styled-content>\n ) diabetes management goals.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We performed a cross\u2010sectional analysis of the baseline data of the International Study of the Prediction of Intra\u2010Abdominal Adiposity and its Relationship with Cardiometabolic risk\/Intra\u2010Abdominal Adiposity (\n INSPIRE ME IAA<\/jats:styled-content>\n ), a 3\u2010year prospective cardiometabolic imaging study conducted in 29 countries. Patients (n\u2009=\u20093991) were divided into four groups: (i) those without type 2 diabetes (\n noT2D<\/jats:styled-content>\n n\u2009=\u20091003 men, n\u2009=\u20091027 women); (ii) those with type 2 diabetes but not treated with diabetes medications (\n T2Dnomeds<\/jats:styled-content>\n n\u2009=\u2009248 men, n\u2009=\u2009198 women); (iii) those with type 2 diabetes and treated with diabetes medications but not yet using insulin (\n T2Dmeds<\/jats:styled-content>\n \u2010ins n\u2009=\u2009591 men, n\u2009=\u2009484 women) and (iv) those with type 2 diabetes and treated with insulin (\n T2Dmeds<\/jats:styled-content>\n +ins n\u2009=\u2009233 men, n\u2009=\u2009207 women). Abdominal and liver adiposity were measured by computed tomography.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fewer patients with high\n VAT<\/jats:styled-content>\n or\n LF<\/jats:styled-content>\n achieved the\n ADA<\/jats:styled-content>\n 's goals for high\u2010density lipoprotein cholesterol (\n HDL<\/jats:styled-content>\n \u2010C) or triglycerides compared to patients with low\n VAT<\/jats:styled-content>\n or\n LF<\/jats:styled-content>\n . Visceral adiposity (p\u2009=\u20090.02 men, p\u2009=\u20090.003 women) and\n LF<\/jats:styled-content>\n (p\u2009=\u20090.0002 men, p\u2009=\u20090.0004 women) increased among patients who met fewer of the\n ADA<\/jats:styled-content>\n treatment criteria, regardless of type 2 diabetes treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Residual cardiometabolic risk exists among patients with type 2 diabetes characterized by elevated\n VAT<\/jats:styled-content>\n and\n LF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12075","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T08:26:14Z","timestamp":1359361574000},"page":"629-641","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of cardiometabolic risk and prevalence of meeting treatment guidelines among patients with type 2 diabetes stratified according to their use of insulin and\/or other diabetic medications: results from\n INSPIRE ME IAA<\/scp>"],"prefix":"10.1111","volume":"15","author":[{"given":"J.","family":"Smith","sequence":"first","affiliation":[{"name":"Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010A.","family":"Nazare","sequence":"additional","affiliation":[{"name":"Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.\u2010L.","family":"Borel","sequence":"additional","affiliation":[{"name":"HP2 Laboratory INSERM U1042, h\u00f4pital universitaire de Grenoble, P\u00f4le DIGI\u2010DUNE d\u00e9partement d'endocrinologie, diab\u00e9tologie, maladie de la nutrition Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Aschner","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana, Hospital Universitario San Ignacio Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Barter","sequence":"additional","affiliation":[{"name":"Heart Research Institute, Camperdown Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Van Gaal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology, Metabolism & Clinical Nutrition Antwerp University Hospital Edegem Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Matsuzawa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Sumitomo Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kadowaki","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Metabolic Diseases, Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ross","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Health Studies Queen's University Kingston ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Brulle\u2010Wohlhueter","sequence":"additional","affiliation":[{"name":"Sanofi Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Alm\u00e9ras","sequence":"additional","affiliation":[{"name":"Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Haffner","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Balkau","sequence":"additional","affiliation":[{"name":"INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse and determinants of early nutrition University Paris Sud 11 Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010P.","family":"Despr\u00e9s","sequence":"additional","affiliation":[{"name":"Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.16.14.1853e"},{"volume-title":"Diabetes Data & Trends","year":"2011","author":"CDC","key":"e_1_2_7_3_1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm124"},{"issue":"1","key":"e_1_2_7_5_1","first-page":"S11","article-title":"Standards of medical care in diabetes. 2012","volume":"35","author":"American Diabetes Association","year":"2012","journal-title":"Diabetes Care"},{"key":"e_1_2_7_6_1","first-page":"S1","article-title":"2008 clinical practice guidelines for the prevention and management of diabetes in Canada","volume":"32","author":"Canadian Diabetes Association","year":"2008","journal-title":"Can J Diabetes"},{"volume-title":"Federation","year":"2004","author":"WHO\/IDF","key":"e_1_2_7_7_1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2550"},{"key":"e_1_2_7_9_1","first-page":"187","article-title":"Techniques for the measurement of visceral fat: a practical guide","volume":"17","author":"Kooy K","year":"1993","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_7_10_1","first-page":"E736","article-title":"Determination of total adipose tissue and body fat in women by computed tomography, 40\u2009K, and tritium","volume":"250","author":"Sjostrom L","year":"1986","journal-title":"Am J Physiol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.3.471"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19890104"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1602-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00986.2005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.06.024"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-56"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.213"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22845"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1464-y"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05488"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","unstructured":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. 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