{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:15:37Z","timestamp":1770077737909,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T00:00:00Z","timestamp":1362009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2013,7]]},"abstract":"\n Aim<\/jats:title>\n \n The aim of the study is to compare the effects of metformin and insulin treatment for gestational diabetes mellitus (\n GDM<\/jats:styled-content>\n ) on vitamin\n \n B\n 12<\/jats:sub>\n <\/jats:styled-content>\n and homocysteine (Hcy) status.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Women with\n GDM<\/jats:styled-content>\n , who met criteria for insulin treatment, were randomly assigned to metformin (n\u2009=\u200989) or insulin (n\u2009=\u200991) in the Adelaide cohort of the metformin in gestational diabetes (\n MiG<\/jats:styled-content>\n ) trial. Fasting serum total vitamin\n \n B\n 12<\/jats:sub>\n <\/jats:styled-content>\n (\n \n TB\n 12<\/jats:sub>\n <\/jats:styled-content>\n ), holotranscobalamin (\n HoloTC<\/jats:styled-content>\n ), a marker of functional\n \n B\n 12<\/jats:sub>\n <\/jats:styled-content>\n status and plasma Hcy concentrations were measured at 20\u201334\u2009weeks (at randomization) and 36\u2009weeks gestation, then at 6\u20138\u2009weeks postpartum.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Circulating\n \n TB\n 12<\/jats:sub>\n <\/jats:styled-content>\n ,\n HoloTC<\/jats:styled-content>\n and Hcy were similar in both treatment groups at each time point. Women who were taking dietary folate supplements at randomization had higher serum\n \n TB\n 12<\/jats:sub>\n <\/jats:styled-content>\n and\n HoloTC<\/jats:styled-content>\n at randomization than those not taking folate. Overall, serum\n \n TB\n 12<\/jats:sub>\n <\/jats:styled-content>\n fell more between randomization and 36\u2009weeks gestation in the metformin group than in the insulin group (metformin: \u221219.7\u2009\u00b1\u20094.7\u2009pmol\/l, insulin: \u22126.4\u2009\u00b1\u20093.6\u2009pmol\/l, p\u2009=\u20090.004). The decrease in serum\n \n TB\n 12<\/jats:sub>\n <\/jats:styled-content>\n during treatment was greater with increasing treatment duration in metformin\u2010treated (p\u2009<\u20090.001), but not in insulin\u2010treated women.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Total, but not bioavailable, vitamin\n \n B\n 12<\/jats:sub>\n <\/jats:styled-content>\n stores were depleted during pregnancy to a greater extent in metformin\u2010treated than in insulin\u2010treated women with\n GDM<\/jats:styled-content>\n , but neither analyte differed between groups at any stage. This adds further evidence supporting metformin as a safe alternative treatment to insulin in\n GDM<\/jats:styled-content>\n . Further investigation is needed to evaluate whether women treated with metformin for longer periods in pregnancy require additional\n \n B\n 12<\/jats:sub>\n <\/jats:styled-content>\n or other supplementation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12080","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T05:26:36Z","timestamp":1360733196000},"page":"660-667","source":"Crossref","is-referenced-by-count":24,"title":["Vitamin\n \n B\n 12<\/sub>\n <\/scp>\n and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment"],"prefix":"10.1111","volume":"15","author":[{"given":"K. L.","family":"Gatford","sequence":"first","affiliation":[{"name":"Robinson Institute and Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Houda","sequence":"additional","affiliation":[{"name":"Robinson Institute and Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. X.","family":"Lu","sequence":"additional","affiliation":[{"name":"Melbourne Pathology Melbourne Victoria Australia"},{"name":"Department of Medicine Monash University Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Coat","sequence":"additional","affiliation":[{"name":"Robinson Institute and Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Baghurst","sequence":"additional","affiliation":[{"name":"Public Health Research Unit, Women's and Children's Hospital, Children Youth and Women's Health Service SA Health North Adelaide South Australia Australia"},{"name":"Discipline of Paediatrics, School of Paediatrics and Reproductive Health University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Owens","sequence":"additional","affiliation":[{"name":"Robinson Institute and Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sikaris","sequence":"additional","affiliation":[{"name":"Melbourne Pathology Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Rowan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics National Women's Health Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M.","family":"Hague","sequence":"additional","affiliation":[{"name":"Robinson Institute and Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.3.579"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-s206"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510001741"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2011.01292.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903550659"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1407"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.05.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707193"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0853"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.9.1227"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6934(03)00009-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508313330902"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2181"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340600855946"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2003.01213.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2005.10.005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767051003678234"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1499-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.8.1367"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.02.011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/clinchem\/48.6.928","article-title":"Longitudinal concentrations of vitamin B12 and vitamin B12\u2010binding proteins during uncomplicated pregnancy","volume":"48","author":"Koebnick C","year":"2002","journal-title":"Clin Chem"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11636"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.009613"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740\u20108709.2011.00364.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(03)00032-5"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-006-0191-6"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00361.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh825"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1516"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb140192.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0793-y"},{"key":"e_1_2_7_33_1","first-page":"377","article-title":"Decreased serum homocysteine in pregnancy","volume":"30","author":"Andersson A","year":"1992","journal-title":"Eur J Clin Chem Clin Biochem"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12080","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:26:09Z","timestamp":1761863169000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,28]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/dom.12080"],"URL":"https:\/\/doi.org\/10.1111\/dom.12080","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,28]]}}}