{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:52:53Z","timestamp":1782445973213,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We investigated postprandial glucagon\u2010like peptide\u20101 (GLP\u20101) responses in pregnant women with and without gestational diabetes mellitus (GDM) and again following delivery when normal glucose tolerance (NGT) was re\u2010established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eleven women with GDM [plasma glucose (PG) concentration at 120\u2009min after a 75\u2010g oral glucose tolerance test (OGTT): 10.0\u2009\u00b1\u20090.9\u2009mM (mean\u2009\u00b1\u2009SD); age: 31\u2009\u00b1\u20096\u2009years; body mass index (BMI): 31.6\u2009\u00b1\u20096.4\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; haemoglobin A1c (HbA1c): 5.6\u2009\u00b1\u20090.5%] and eight pregnant women with NGT (PG\n                      <jats:sub>120min, OGTT<\/jats:sub>\n                      : 5.7\u2009\u00b1\u20090.7\u2009mM; age: 28\u2009\u00b1\u20093\u2009years; BMI: 29.7\u2009\u00b1\u20095.4\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; HbA1c: 5.4\u2009\u00b1\u20090.3%) were investigated with a 4\u2010h liquid meal test during third trimester (TT) and 3\u20134\u2009months postpartum (PP). All patients with GDM re\u2010established NGT following delivery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pregnancy was associated with low postprandial GLP\u20101 responses. Patients with GDM exhibited reduced postprandial GLP\u20101 responses compared to their PP levels [area under curve (AUC): 5.5\u2009\u00b1\u20091.3 vs. 8.4\u2009\u00b1\u20093.2\u2009nM\u2009\u00d7\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      =0.005], but the difference among NGT women (7.3\u2009\u00b1\u20092.8 vs. 8.8\u2009\u00b1\u20092.0\u2009nM\u2009\u00d7\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      =0.066) was not statistically significant. Pregnancy did not influence postprandial responses of the other incretin hormone glucose\u2010dependent insulinotropic polypeptide (GIP) in any of the groups, but GDM patients were characterized by greater postprandial GIP responses during both TT and PP compared to NGT subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pregnancy is associated with reduced postprandial GLP\u20101 responses (most pronounced in patients with GDM) that normalize after delivery. In contrast, postprandial GIP responses seem unaffected by pregnancy but is increased in GDM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.12082","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T13:09:09Z","timestamp":1360760949000},"page":"713-720","source":"Crossref","is-referenced-by-count":41,"title":["Reduced postprandial\n                    <scp>GLP<\/scp>\n                    \u20101 responses in women with gestational diabetes mellitus"],"prefix":"10.1111","volume":"15","author":[{"given":"L.","family":"Bonde","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark"},{"name":"Diabetes Research Division, Department of Internal Medicine Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vilsb\u00f8ll","sequence":"additional","affiliation":[{"name":"Diabetes Research Division, Department of Internal Medicine Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. I.","family":"Bagger","sequence":"additional","affiliation":[{"name":"Diabetes Research Division, Department of Internal Medicine Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Svare","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Herlev Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Diabetes Research Division, Department of Internal Medicine Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-826158"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02427280"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"A482.","article-title":"Secretion of Glucagon\u2010Like Peptide\u20101 in Patients With Type 2 Diabetes Mellitus \u2010 Systematic Review and Meta\u2010Analysis of Clinical Studies","volume":"61","author":"Calanna S","year":"2012","journal-title":"Diabetes"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.8.7750"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1350425"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051444"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02579.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.9.1640"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0958"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1422-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1511-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274255"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm727"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2006.4.84"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0965"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.4.535"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.10.3575"},{"key":"e_1_2_7_19_1","first-page":"783","article-title":"A general regression procedure for method transformation. 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