{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:05:44Z","timestamp":1765609544332,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T00:00:00Z","timestamp":1363132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2013,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aims<\/jats:title>\n \n This study assessed the efficacy and safety of once\u2010daily insulin initiation using insulin detemir (detemir) or insulin glargine (glargine) added to existing metformin in type 2 diabetes (\n T2D<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This 26\u2010week, multinational, randomized, treat\u2010to\u2010target trial involved 457 insulin\u2010na\u00efve adults with\n T2D<\/jats:styled-content>\n (\n HbA1c<\/jats:styled-content>\n 7\u20139%). Detemir or glargine was added to current metformin therapy [any second oral antidiabetic drug (\n OAD<\/jats:styled-content>\n ) discontinued] and titrated to a target fasting plasma glucose (\n FPG<\/jats:styled-content>\n ) \u226490\u2009mg\/dl (\u22645.0\u2009mmol\/l). Primary efficacy endpoint was change in\n HbA1c<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean (s.d.)\n HbA1c<\/jats:styled-content>\n decreased with detemir and glargine by 0.48 and 0.74%\u2010points, respectively, to 7.48% (0.91%) and 7.13% (0.72%) [estimated between\u2010treatment difference, 0.30 (95%\n CI<\/jats:styled-content>\n : 0.14\u20130.46)]. Non\u2010inferiority for detemir at the\n a priori<\/jats:italic>\n level of 0.4%\u2010points was not established. The proportions of patients reaching\n HbA1c<\/jats:styled-content>\n \u2009\u2264\u20097% at 26\u2009weeks were 38% and 53% (p\u2009=\u20090.026) with detemir and glargine, respectively.\n FPG<\/jats:styled-content>\n decreased \u223c43.2\u2009mg\/dl (\u223c2.4\u2009mmol\/l) in both groups [non\u2010significant (NS)]. Treatment satisfaction was good for both insulins. Hypoglycaemia, which occurred infrequently, was observed less with detemir than glargine [rate ratio 0.73 (95%\n CI<\/jats:styled-content>\n 0.54\u20130.98)]. The proportions of patients reaching\n HbA1c<\/jats:styled-content>\n \u2009\u2264\u20097% without hypoglycaemia in the detemir and glargine groups were 32% and 38% (\n NS<\/jats:styled-content>\n ), respectively. Weight decreased with detemir [\u22120.49 (3.3) kg] and increased with glargine [+1.0 (3.1) kg] (95%\n CI<\/jats:styled-content>\n for difference: \u22122.17 to \u22120.89\u2009kg).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n While both detemir and glargine, when added to metformin therapy, improved glycaemic control, glargine resulted in greater reductions in\n HbA1c<\/jats:styled-content>\n , while detemir demonstrated less weight gain and hypoglycaemia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12083","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T17:00:12Z","timestamp":1361293212000},"page":"729-736","source":"Crossref","is-referenced-by-count":51,"title":["Once\u2010daily initiation of basal insulin as add\u2010on to metformin: a 26\u2010week, randomized, treat\u2010to\u2010target trial comparing insulin detemir with insulin glargine in patients with type 2 diabetes"],"prefix":"10.1111","volume":"15","author":[{"given":"L.","family":"Meneghini","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes & Metabolism University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kesavadev","sequence":"additional","affiliation":[{"name":"Jothydev's Diabetes and Research Center Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Demissie","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S S\u00f8borg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nazeri","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S S\u00f8borg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hollander","sequence":"additional","affiliation":[{"name":"Baylor Endocrine Center Baylor University Medical Center Dallas TX 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