{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:23:41Z","timestamp":1792787021221,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T00:00:00Z","timestamp":1389830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["R01DK098687"],"award-info":[{"award-number":["R01DK098687"]}]},{"name":"NIH","award":["R01DK089641"],"award-info":[{"award-number":["R01DK089641"]}]},{"name":"NIH","award":["P30DK072476"],"award-info":[{"award-number":["P30DK072476"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2014,8]]},"abstract":"\n Recent reports suggest that short\u2010term pharmacological carnitine palmitoyltransferase 1 (Cpt1) inhibition improves skeletal muscle glucose tolerance and insulin sensitivity. Although this appears promising for the treatment of diabetes, these Cpt1 inhibitors are not specific to skeletal muscle and target multiple Cpt1 isoforms. To assess the effects of inhibiting the Cpt1b isoform we generated mice with a heart\u2010 and skeletal muscle\u2010specific deletion of the Cpt1b,\n \n Cpt1b\n HM<\/jats:sup>\n <\/jats:styled-content>\n \u2212\/\u2212<\/jats:sup>\n . These mice seem to develop normally with similar bodyweights as control mice. However, premature mortality was observed by 15\u2009weeks of age in the\n \n Cpt1b\n HM<\/jats:sup>\n <\/jats:styled-content>\n \u2212\/\u2212<\/jats:sup>\n mice. The hearts of\n \n Cpt1b\n HM<\/jats:sup>\n <\/jats:styled-content>\n \u2212\/\u2212<\/jats:sup>\n mice were four times the size of controls.\n \n Cpt1b\n HM<\/jats:sup>\n <\/jats:styled-content>\n \u2212\/\u2212<\/jats:sup>\n mice were also subject to stress\u2010induced seizures that accompanied an increased risk for premature mortality. Our data suggests that prolonged Cpt1b inhibition poses severe cardiac risk and emphasizes that attempts to improve insulin sensitivity by targeting Cpt1 with current inhibitors is not viable.\n <\/jats:p>","DOI":"10.1111\/dom.12248","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T01:55:01Z","timestamp":1386899701000},"page":"757-760","source":"Crossref","is-referenced-by-count":59,"title":["Inhibition of carnitine palymitoyltransferase1b induces cardiac hypertrophy and mortality in mice"],"prefix":"10.1111","volume":"16","author":[{"given":"K. R.","family":"Haynie","sequence":"first","affiliation":[{"name":"Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vandanmagsar","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"Wicks","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. L.","family":"Mynatt","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Louisiana State University System Baton Rouge LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206868109"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0259"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12932"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.22.2248"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.075978"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.198663"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20082159"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.63.6.1036"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200294-JLR200"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1999.2938"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T23:48:15Z","timestamp":1760399295000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,16]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/dom.12248"],"URL":"https:\/\/doi.org\/10.1111\/dom.12248","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,16]]}}}